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Book Cover
Author Novartis Foundation Symposium on Understanding How Gene-Environment Interactions Work to Predict Disorder: A Lifecourse Approach (2007 : University of Otago)

Title Genetic effects on environmental vulnerability to disease / edited by Michael Rutter
Published Chicester, England ; Hoboken, N.J. : Wiley-Blackwell, 2008
Online access available from:
Wiley Online Books    View Resource Record  


Description 1 online resource (viii, 223 pages) : illustrations
Series Novartis Foundation symposium ; 293
Novartis Foundation symposium ; 293
Contents Introduction : whither gene-environment interactions?? Michael Rutter -- Gene-environment interaction : overcoming methodological challenges / Rudolf Uher -- Gene-environment interaction and behavioral disorders : a developmental perspective based on endophenotypes / Marco Battaglia, Cecilia Marino, Michel Maziade, Massimo Molteni and Francesca D'Amato -- Use of monozygotic twins to investigate the relationship between 5HTTLPR genotype, depression and stressful life events : an application of item response theory / Naomi R. Wray, William L. Coventry, Michael R. James, Grant W. Montgomery, Lindon J. Eaves and Nicholas G. Martin -- Role of gene-stress interactions in gene finding studies / Harold Snieder, Xiaoling Wang, Vasiliki Lagou, Brenda W.J.H. Penninx, Harriëtte Riese and Catharina A. Hartman -- Practice and public policy in the era of gene-environment interactions / Kenneth A. Dodge -- Gene-environment interaction and the metabolic syndrome / Kristi B. Adamo and Frédérique Tesson -- Longitudinal studies of gene-environment interaction in common diseases -- good value for money? / Stephen P. Robertson and Richie Poulton -- Gene-environment interactions in breast cancer / Kee-Seng Chia -- Unbiased forward genetics and systems biology approaches to understanding how gene-environment interactions work to predict susceptibility and outcomes of infections / Malak Kotb, Nourtan Fathey, Ramy Aziz, Sarah Rowe, Robert W. Williams and Lu Lu -- Gene-environment interactions in environmental lung diseases / Steven R. Kleeberger and Hye-Youn Cho -- Gene-environment interaction in complex diseases : asthma as an illustrative case / Fernando D. Martinez -- Conclusions : taking stock and looking ahead / Michael Rutter
Summary Much research has attempted to show direct linear relations between genes and disorder. However, scientists have been discouraged by inconsistent findings based on this simple gene-phenotype approach. The alternative approach is to incorporate information about the environment. A gene-environment interaction approach assumes that environmental pathogens cause disorder, whereas genes influence susceptibility to environmental pathogens. This book brings together contributions from experts from multiple disciplines who discuss:.:.; How epidemiological cohort studies can better integrate physiolog
Analysis Disease
Environmental vulnerability
Gene-environment interactions
Genetic effects
Notes Proceedings of the Novartis Foundation Symposium on Understanding How Gene-Environment Interactions Work to Predict Disorder: A Lifecourse Approach, held at the University of Central Otago, Dunedin, N.Z., Nov. 8-9, 2007
Bibliography Includes bibliographical references and indexes
Notes Print version record
Subject Disease susceptibility -- Genetic aspects -- Congresses.
Environmentally induced diseases -- Genetic aspects -- Congresses.
Disease Susceptibility -- etiology.
Environmental Exposure -- adverse effects.
Genetic Predisposition to Disease -- genetics.
Genre/Form Conference papers and proceedings.
Conference papers and proceedings.
Form Electronic book
Author Rutter, Michael, 1933-
Novartis Foundation.
Wiley InterScience (Online service)
ISBN 0470696788
0470696796 (electronic bk.)
9780470696798 (electronic bk.)