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E-book

Title Nutrigenetics and nutrigenomics / volume editors, Artemis P. Simopoulos, José M. Ordovas
Published Basel ; New York : S. Karger, ©2004

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Description 1 online resource (xii, 324 pages) : illustrations
Series World review of nutrition and dietetics ; v. 93
World review of nutrition and dietetics ; v. 93.
Contents Contents -- Preface -- Genetic Variation: Nutritional Implications -- Heritability -- Genetic Diversity: Ethnic Differences and Gene Variants -- Genetic Variation, Dietary Sodium and the Response of Blood Pressure -- Genetic Variation, Omega�3 Fatty Acids and Inflammation -- Omega�6 and Omega�3 Fatty Acids and Prostaglandin Metabolism -- Omega�3 Fatty Acids, Genetic Variation and Cytokines -- Genetic Variation, Interleukin-6 and Cardiovascular Disease -- The Future of Genetic Nutrition: Nutrigenetics/Nutrigenomics -- The Potential for Novel Foods
Conclusions and RecommendationsReferences -- Gene: Environment Interactions and Coronary Heart Disease Risk -- Coronary Heart Disease � An Example of a Complex Disorder -- Statistical Interaction versus Biological Interaction -- Gene: Environment Interaction and How to Analyse the Data -- Measuring Genetic and Environmental Factors -- Environmental Risk Factors -- Genetic Risk Factors -- Gene: Diet Interactions -- Impact of Smoking on Lipid Levels and CHD Risk -- APOE: Smoking Interaction and CHD Risk
Alcohol Consumption, Alcohol Dehydrogenase Gene and CHD RiskConclusion -- Acknowledgement -- References -- Genes, Diet and Plasma Lipids: The Evidence from Observational Studies -- Gene by Diet Interactions -- Methodological Issues -- Dietary Assessment -- Genotyping and Quality Control Measures -- Levels of Interaction -- Gene-Diet Interactions Modulating Plasma Lipid Levels -- Familial Hypercholesterolemia -- Genes with Minor Effects but High Allele Frequencies -- Apolipoprotein A-I -- Apolipoprotein AP-IV (APOA4) -- Apolipoprotein CIII (APOC3)
Apolipoprotein EHepatic Lipase -- Peroxisome Proliferator-Activated Receptor-gamma -- 5-Lipoxygenase (ALOX5) -- Conclusions -- Acknowledgements -- References -- Dynamic Relationships between the Genome and Exposures to Environments as Causes of Common Human Diseases -- The Problem -- Disease Susceptibility -- Population Genetics -- Two Different Research Strategies for Studying Genetic Architecture -- Disease Is a 'Simple' Consequence of Variations in Independent Causal Agents -- Disease Is a Consequence of the 'Complex' Organization of Interacting Agents
ConclusionsAcknowledgments -- References -- Achieving Balance in the Omega� 6/ Omega� 3 Ratio through Nutrigenomics -- Methods -- Construction of Expression Vectors -- Production of Transgenic Mice -- Animal Feeding -- Lipid Analysis -- Results -- Discussion -- Acknowledgements -- References -- Nutrients and Gene Expression -- Direct and Indirect Regulation of Gene Expression by Nutrients in Simple and Complex Organisms -- Nutrients as Ancestral Modulators of Gene Expression -- Examples of Nutrient Control of Gene Expression -- Amino Acids
Summary For the first time, international scientists describe the advances in genetics and nutrition by combining methods of molecular biology with those of functional genetics, also known as systems biology. This book provides the latest data on genetic variation and dietary response, nutrients and gene expression, and the contribution molecular biology has given to systems biology. It also includes a comprehensive critique of genetic association studies in defining the risk of chronic diseases and concludes that molecular diagnostic tests will eventually affect every area of health care from individual risk prediction, early diagnosis of disease, and determination of optimal treatment regimens, to monitoring treatment effectiveness. The appendix contains an extensive glossary of the newly emerging terminology, as well as recommendations for genetic screening. This publication is an essential tool for the future work of all physicians, nutritionists, dietitians, geneticists, physiologists, molecular biologists, anthropologists, food technologists, policy makers, ethicists and educators
Bibliography Includes bibliographical references and index
Notes Master and use copy. Digital master created according to Benchmark for Faithful Digital Reproductions of Monographs and Serials, Version 1. Digital Library Federation, December 2002. http://purl.oclc.org/DLF/benchrepro0212 MiAaHDL
digitized 2010 HathiTrust Digital Library committed to preserve pda MiAaHDL
Print version record
Subject Nutrition -- Genetic aspects.
Nutrient interactions.
Genetic polymorphisms.
Gene expression.
Genomics.
Nutritionally induced diseases -- Genetic aspects
Nutrition -- Requirements.
Genetic Diseases, Inborn -- diet therapy
Nutrigenomics
Polymorphism, Genetic
Gene Expression
Genomics
Fatty Acids, Omega-3 -- metabolism
Gene Expression -- physiology
Genetic Variation -- physiology
Nutritional Requirements
Nutrition -- Requirements
Gene expression
Genetic polymorphisms
Genomics
Nutrient interactions
Nutrition -- Genetic aspects
Maladies génétiques congénitales -- diétothérapie.
Acides gras omega-3 -- métabolisme.
Besoins nutritifs.
Variation génétique -- physiologie.
Umwelt
Krankheit
Diät
Genomik
Genetische Variabilität
Genetik
Ernährungskrankheit
Ernährung
Nutrição (genética)
Polimorfismo (genética)
Expressão gênica.
Doenças nutricionais e metabólicas (genética)
Biologia molecular.
Doenças genéticas (dietoterapia)
Ácidos graxos omega 3 (metabolismo)
Necessidades nutricionais.
Expressão gênica (fisiologia)
Variação genética.
Doença crônica.
Maladies de la nutrition -- Aspect génétique.
Polymorphisme génétique.
Expression génique.
Génétique.
Maladies d'origine nutritionnelle -- Aspect génétique.
Form Electronic book
Author Simopoulos, Artemis P., 1933-
Ordovas, J. M
LC no. 2004013501
ISBN 3318011126
9783318011128