| Description |
1 online resource (xix, 208 pages) : illustrations |
| Series |
Advances in experimental medicine and biology ; v. 769 |
|
Advances in experimental medicine and biology ; v. 769. 0065-2598
|
| Contents |
Tandem repeat polymorphisms : mediators of genetic plasticity, modulators of biological diversity and dynamic sources of disease susceptibility / Anthony J. Hannan -- Evolution of simple sequence repeats as mutable sites / David G. King -- Single amino acid and trinucleotide repeats : function and evolution / Noel Faux -- Promoter microsatellites as modulators of human gene expression / Sterling M. Sawaya [and others] -- Dynamic mutations : where are they now? / Clare L. Van Eyk and Robert I. Richards -- Unstable mutations in the FMR1 gene and the phenotypes / Danuta Loesch and Randi Hagerman -- Molecular pathways to polyglutamine aggregation / Amy L. Robertson and Stephen P. Bottomley -- Polyglutamine aggregation in Huntington and related diseases / Saskia Polling, Andrew F. Hill and Danny M. Hatters -- Selective neurodegeneration, neuropathology and symptom profiles in Huntington's disease / Henry J. Waldvogel [and others] -- Kennedy's disease : clinical significance of tandem repeats in the androgen receptor / Jeffrey D. Zajac and Mark Ng Tang Fui -- Characterising the neuropathology and neurobehavioural phenotype in Friedreich ataxia : a systematic review / Louise A. Corben [and others] -- Polyalanine tract disorders and neurocognitive phenotypes / Cheryl Shoubridge and Jozef Gecz |
| Summary |
This book addresses the role of tandem repeat polymorphisms (TRPs) in genetic plasticity, evolution, development, biological processes, neural diversity, brain function, dysfunction and disease. There are hundreds of thousands of unique tandem repeats in the human genome and their polymorphic distributions have the potential to greatly influence functional diversity and disease susceptibility. Recent discoveries in this expanding field are critically reviewed and discussed in a range of subsequent chapters, with a focus on the role of TRPs and their various gene products in evolution, development, diverse molecular and cellular processes, brain function and disease |
| Bibliography |
Includes bibliographical references and index |
| Notes |
Print version record |
| In |
Springer eBooks |
| Subject |
Mutation (Biology)
|
|
Genetic polymorphisms.
|
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Polymorphism, Genetic
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Tandem Repeat Sequences
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Heredodegenerative Disorders, Nervous System -- genetics
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Mutation
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medicines (material)
|
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SCIENCE -- Life Sciences -- Genetics & Genomics.
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Genetic polymorphisms
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Mutation (Biology)
|
| Form |
Electronic book
|
| Author |
Hannan, Anthony J., 1969-
|
| ISBN |
9781461454342 |
|
1461454344 |
|
