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Title Human genome epidemiology : building the evidence for using genetic information to improve health and prevent disease / edited by Muin J. Khoury [and others]
Edition 2nd ed
Published New York ; Oxford : Oxford University Press, 2010


Description 1 online resource (xxiii, 676 pages) : illustrations
Contents Human genome epidemiology: the road map revisited -- Principles of analysis of germline genetics -- The public health genomics enterprise -- Navigating the evolving knowledge of human genetic variation in health and disease -- The global emergence of epidemiological biobanks: opportunities and challenges -- Case-control and cohort studies in the age of genome-wide associations -- The emergence of networks in human genome epidemiology: challenges and opportunities -- Design and analysis issues in genome-wide association studies -- The challenge of assessing complex gene-environment and gene-gene interactions -- STrengthening the REporting of genetic association studies (STREGA)-an extension of the STROBE statement -- Integration of the evidence on gene-disease associations: methods of HuGE reviews -- Genome-wide association studies, field synopses, and the development of the knowledge base on genetic variation and human diseases -- Colorectal cancer -- Childhood leukemias -- Bladder cancer -- Type 2 diabetes -- Osteoporosis -- Preterm birth -- Coronary heart disease -- Schizophrenia -- Mendelian randomization: the contribution of genetic epidemiology to elucidating environmentally modifiable causes of disease -- Evaluation of predictive genetic tests for common diseases: bridging epidemiological, clinical, and public health measures -- The evaluation of genomic applications in practice and prevention (EGAPP) initiative: methods of the EGAPP working group -- Rapid, evidence-based reviews of genetic tests -- Role of social and behavioral research in assessing the utility of genetic information -- Assessing the evidence for clinical utility in newborn screening -- The role of epidemiology in assessing the potential clinical impact of pharmacogenomics -- The human epigenome and cancer -- The use of family history in public health practice: the epidemiologic view -- Cytochrome P450 testing in the treatment of depression -- A rapid-ACCE review of CYP2CP and VKORC1 allele testing to inform warfarin dosing in adults at elevated risk for thrombotic events to avoid serious bleeding -- Hereditary hemochromatosis: population screening for gene mutations
Summary This text describes the role that epidemiologic methods play in the continuum from gene discovery to the development and application of genetic tests. It provides a foundation that should help researchers, policy makers and practitioners integrate genomics into medical and public health practice
Bibliography Includes bibliographical references and index
Notes Print version record
Subject Genetic disorders -- Epidemiology
Medical genetics -- Methodology
Genetic screening.
Human genome.
Genetics, Medical -- methods
Genetic Diseases, Inborn -- epidemiology
Genetic Predisposition to Disease -- epidemiology
Genetic Testing
Genome, Human
Human genome.
Genetic screening.
Form Electronic book
Author Khoury, Muin J
ISBN 9780195398441