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Title Systems analysis of human multigene disorders / Natalia Maltsev, Andrey Rzhetsky, T. Conrad Gilliam, editors
Published New York : Springer, 2014

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Description 1 online resource (134 pages) : illustrations
Series Advances in Experimental Medicine and Biology ; 799
Advances in experimental medicine and biology ; v. 799.
Contents Wellness and Health Omics Linked to the Environment: The WHOLE Approach to Personalized Medicine / Greg Gibson -- Characterizing Multi-omic Data in Systems Biology / Christopher E. Mason, Sandra G. Porter and Todd M. Smith -- High-Throughput Translational Medicine: Challenges and Solutions / Dinanath Sulakhe, Sandhya Balasubramanian, Bingqing Xie, Eduardo Berrocal, Bo Feng [and 9 others] -- Computational Approaches for Human Disease Gene Prediction and Ranking / Cheng Zhu, Chao Wu, Bruce J. Aronow and Anil G. Jegga -- A Personalized Treatment for Lung Cancer: Molecular Pathways, Targeted Therapies, and Genomic Characterization / Thomas Hensing, Apoorva Chawla, Rishi Batra and Ravi Salgia
Wellness and Health Omics Linked to the Environment: the WHOLE approach to personalized medicine -- Characterizing Multi-omic Data in Systems Biology -- High-throughput Translational Medicine: Challenges and Solutions -- Computational approaches for human disease gene prediction and ranking -- A Personalized Treatment for Lung Cancer: Molecular Pathways, Targeted Therapies, and Genomic Characterization -- Index
Summary Understanding the genetic architecture underlying complex multigene disorders is one of the major goals of human genetics in the upcoming decades. Advances in whole genome sequencing and the success of high throughput functional genomics allow supplementing conventional reductionist biology with systems-level approaches to human heredity and health as systems of interacting genetic, epigenetic, and environmental factors. This integrative approach holds the promise of unveiling yet unexplored levels of molecular organization and biological complexity. It may also hold the key to deciphering the multigene patterns of disease inheritance
Bibliography Includes bibliographical references and index
Notes Online resource; title from PDF title page (ebrary, viewed January 5, 2014)
Subject Medicine.
Human genetics.
Biological models.
Genetics, Medical -- statistics & numerical data
Medicine
Genetics
Models, Biological
medicines (material)
medicine (discipline)
HEALTH & FITNESS -- Diseases -- General.
MEDICAL -- Clinical Medicine.
MEDICAL -- Diseases.
MEDICAL -- Evidence-Based Medicine.
MEDICAL -- Internal Medicine.
Biological models
Human genetics
Medicine
Form Electronic book
Author Maltsev, Natalia, editor
Rzhet︠s︡kiĭ, A. I︠U︡. (Andreĭ I︠U︡rʹevich), editor.
Gilliam, T. Conrad, editor
ISBN 9781461487784
1461487781
1461487773
9781461487777