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Title The insulinotropic gut hormone glucagon-like peptide-1 / volume editors, H.C. Fehmann, B. Göke
Published Basel ; New York : Karger, 1997


Description 1 online resource (viii, 240 pages) : illustrations
Series Frontiers in diabetes ; vol. 13
Frontiers in diabetes ; vol. 13.
Contents Design of the Entero-Insular Axis / W. Creutzfeldt -- Proglucagon Gene Structure and Regulation of Expression / J.F. Habener -- Posttranslational Processing of Proglucagon and Postsecretory Fate of Proglucagon Products / J.J. Holst, C. Orskov and B. Hartmann [and others] -- Morphological Aspects of GLP-1 Expression in the Intestine / R. Eissele -- Release of GLP-1 into the Circulation / P.L. Brubaker -- Glucagon-Like Peptide-1 Receptor in Relation to Its Ligand / R. Goke, A. Hareter and T. Vahl [and others] -- Effects of GLP-1 on Islet Hormone Secretion: Experimental Studies / H.C. Fehmann -- In vivo Regulation of Human Islet Hormone Secretion by Glucagon-Like Peptide-1 / D.A. D'Alessio and J.W. Ensinck -- Signal Transduction of GLP-1 / H.-P. Bode and B. Goke -- Islet Genes Regulated by GLP-1 / H.C. Fehmann -- Glucagon-Like Peptide-1 and the Glucose Competence Concept of Pancreatic Beta-Cell Function / G.G. Holz and C.A. Leech
Summary Glucagon-like peptide-1 (GLP-1) is a promising new therapeutic tool for the treatment of diabetes. Since the first reports describing its potent insulinotropic activity were published about a decade ago, knowledge of the incretin hormones, and GLP-1 in particular, has increased significantly. This timely volume summarizes what is now known about the molecular biology, physiology and pharmacology of GLP-1. Thorough coverage is given to the physiology of the hormone, including its generation, release and actions at pancreatic and extrapancreatic tissues. The intracellular mechanisms of GLP-1 are also described in detail. Discussion of the molecular biology includes the structure and functions of the genes coding for proglucagon and the GLP-1 receptor. A special feature of the book is the clinical information provided which includes data on the expression and release of GLP-1 and its potential use as a therapeutic agent for diabetes. Presenting the results of exciting new research, this book will be a valuable reference for endocrinologists, gastroenterologists, pharmacologists, physiologists and biochemists interested in this important hormone
Bibliography Includes bibliographical references and indexes
Notes Master and use copy. Digital master created according to Benchmark for Faithful Digital Reproductions of Monographs and Serials, Version 1. Digital Library Federation, December 2002. MiAaHDL
Print version record
digitized 2010 HathiTrust Digital Library committed to preserve pda MiAaHDL
Subject Glucagon-like peptide 1.
Glucagon-Like Peptides -- metabolism
Diabetes Mellitus -- drug therapy
Glucagon -- metabolism
Glucagon -- therapeutic use
Peptide Fragments
Glucagon-Like Peptide 1
Glucagon-like peptide 1
Peptides glucagon-like -- Métabolisme.
Glucagon -- usage thérapeutique.
Fragments peptidiques.
Diabète -- Traitement médicamenteux.
Glucagon -- Métabolisme.
Insuline -- Métabolisme.
Diabète -- Chimiothérapie.
Form Electronic book
Author Fehmann, H.-C. (Hans-Christoph)
Göke, B. (Burkhard)
S. Karger (Firm)
ISBN 9783318019346