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Title Glutamate-related biomarkers in drug development for disorders of the nervous system : workshop summary / Diana E. Pankevich, Miriam Davis, and Bruce M. Altevogt, rapporteurs ; Forum on Neuroscience and Nervous System Disorders, Board on Health Sciences Policy, Institute of Medicine of the National Academies
Published Washington, D.C. : National Academies Press, ©2011


Description 1 online resource (xii, 61 pages) : illustrations (some color)
Contents Introduction -- Overview of the Glutamatergic System -- Glutamate Biomarkers -- Treatment Implications of Biomarkers -- Challenges and Opportunities -- Appendix A: References -- Appendix B: Registered Attendees -- Appendix C: Agenda
Summary Glutamate is the most pervasive neurotransmitter in the central nervous system (CNS). Despite this fact, no validated biological markers, or biomarkers, currently exist for measuring glutamate pathology in CNS disorders or injuries. Glutamate dysfunction has been associated with an extensive range of nervous system diseases and disorders. Problems with how the neurotransmitter glutamate functions in the brain have been linked to a wide variety of disorders, including schizophrenia, Alzheimer's, substance abuse, and traumatic brain injury. These conditions are widespread, affecting a large portion of the United States population, and remain difficult to treat. Efforts to understand, treat, and prevent glutamate-related disorders can be aided by the identification of valid biomarkers. The Institute of Medicine's Forum on Neuroscience and Nervous System Disorders held a workshop on June 21-22, 2010, to explore ways to accelerate the development, validation, and implementation of such biomarkers. This book investigates promising current and emerging technologies, and outlines strategies to procure resources and tools to advance drug development for associated nervous system disorders. Moreover, this report highlights presentations by expert panelists, and the open panel discussions that occurred during the workshop
Bibliography Includes bibliographical references (pages 39-43)
Notes Print version record
Subject Biochemical markers -- Congresses
Drug development -- Congresses
Nervous system -- Diseases -- Congresses
Neuropharmacology -- Congresses
Biomarkers, Pharmacological
Central Nervous System Diseases -- diagnosis
Central Nervous System -- drug effects
Drug Discovery
Glutamic Acid -- adverse effects
Neuropharmacology -- methods
MEDICAL -- Allied Health Services -- Medical Technology.
MEDICAL -- Biotechnology.
MEDICAL -- Family & General Practice.
MEDICAL -- Lasers in Medicine.
Biochemical markers
Drug development
Nervous system -- Diseases
Genre/Form proceedings (reports)
Conference papers and proceedings
Conference papers and proceedings.
Actes de congrès.
Form Electronic book
Author Pankevich, Diana E., 1975-
Altevogt, Bruce M.
Davis, Miriam (Medical writer)
Institute of Medicine (U.S.). Forum on Neuroscience and Nervous System Disorders.
ISBN 9780309212229