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Title Thiol metabolism and redox regulation of cellular functions / [edited by] Alfonso Pompella, Gabor Banhegyi, Maria Wellman-Rousseau
Published Amsterdam ; Washington, DC : IOS Press, ©2002


Description 1 online resource (xii, 350 pages) : illustrations
Series NATO science series. Series I, Life and behavioural sciences, 1566-7693 ; v. 347
NATO science series. Series I, Life and behavioural sciences ; v. 347. 1566-7693
Contents Oxidative signaling and glutathione synthesis -- Cell survival and changes in gene expression in cells unable to synthesize glutathione -- Role of glutathione in the regulation of liver metabolism -- Glutathione transport in the endo/sarcoplasmic reticulum -- Role of ascorbate in oxidative protein folding -- Cytophotometric investigations on oscillating thiol-disulfide equilibria and oxidized protein sulfur -- Protection by pantothenic acid against apoptosis and cell damage by oxygen free radicals -- the role of glutathione -- Thiols as major determinants of the total antioxidant capacity -- Enzymes of the thio9l-dependent hydroperoxide metabolism in pathogens as potential drug targets -- Is there a role of glutathione peroxidases in signaling and differentiation? -- Multidrug resistance-associated proteins: export pumps for conjugates with glutathione, glucuronate or sulfate -- Detoxification of eletrophilic compounds by glutathione s-transferase catalysis: determinants of individual response to chemical carcinogens and chemotherapeutic drugs? -- Transcriptional regulation of glutathione s-transferase P1-1 in human leukemia -- Mechanism of [gamma]-glutamyltranspeptidase folding and activation in the endoplasmic reticulum
The role of [gamma]-glutamyl transpeptidase in the biosynthesis of glutathione -- Role of [gamma]-glutamyltransferase in the homeostasis of glutathione during oxidative and nitrosative stress -- The importance of gamma-glutamyl transferase in lung glutathione homeostasis and antioxidant defense -- The role of gamma-glutamyltranspeptidase in the metabolism and cytotoxicity of 4-hydroxynonenal-glutathione conjugate: evidence and hypothesis -- [gamma]-glutamyltransferase-dependent prooxidant reactions: a factor in multiple processes -- Serum gamma-glutamyl transpeptidase: a prognostic marker in cardiovascular diseases -- Lipoic acid: a multifunctional antioxidant -- Is glutathione an important neuroprotective effector molecule against amyloid beta toxicity? -- Antioxidants in cancer therapy: is there a rationale to recommend antioxidants during cancer therapy? -- Disulfide exchange in CD4 -- Redox regulation in protein folding and chaperone function -- Reduction of the endoplasmic reticulum accompanies the oxidative damage of diabetes mellitus -- Analytical developments in the assay of intra- and extracellular GSH homeostasis -- Signalling potential and protein modifying ability of physiological thiols -- Redox signaling and the map kinase pathways -- Redox regulation of mitochondrial permeability transition: contrasting effects of lipoic acid and its positively charged analog LA-plus -- Redox state of glutathione and
Summary This volume contains contributions by some of the leading scientists in the field of thiol oxidation/reduction (redox) biochemistry. It is focused on the biological/pathophysiological implications of newly-discovered functions of cellular thiols, such as glutathione in the first place
Notes "Published in cooperation with NATO Scientific Affairs Division."
"Proceedings of the NATO Advanced Research Workshop on Thiol Metabolism and Redox Regulation of Cellular Functions, 10-13 April 2002, Pisa, Italy"--Title page verso
Bibliography Includes bibliographical references and index
Notes Master and use copy. Digital master created according to Benchmark for Faithful Digital Reproductions of Monographs and Serials, Version 1. Digital Library Federation, December 2002. MiAaHDL
Print version record
digitized 2010 HathiTrust Digital Library committed to preserve pda MiAaHDL
Subject Antioxidants -- Congresses
Thiols -- Physiological effect -- Congresses
Glutathione -- Physiological effect -- Congresses
Oxidation-reduction reaction -- Congresses
Cell respiration -- Congresses
Oxidation-reduction reaction.
Cell physiology.
Cell Physiological Phenomena
MEDICAL -- Health Risk Assessment.
Cell physiology
Cell respiration
Glutathione -- Physiological effect
Oxidation-reduction reaction
Thiols -- Physiological effect
Genre/Form proceedings (reports)
Conference papers and proceedings
Conference papers and proceedings.
Actes de congrès.
Form Electronic book
Author Pompella, Alfonso
Bánhegyi, Gábor
Wellman-Rousseau, Maria
NATO Advanced Research Workshop on Thiol Metabolism and Redox Regulation of Cellular Functions (2002 : Pisa, Italy)
LC no. 2002111980
ISBN 0585458707