| Description |
1 online resource |
| Series |
SpringerBriefs in neuroscience, 2191-558X |
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SpringerBriefs in neuroscience.
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| Contents |
880-01 Presynaptic glutamate transport in the brain -- Cholesterol and its role in synaptic transmission -- Effects of cholesterol-depleting agent methyl-b-cyclodextrin (MbCD) on the functional state of brain nerve terminals -- The extracellular level and uptake of glutamate in cholesterol-deficient nerve terminals -- Unstimulated and exocytotic glutamate release from cholesterol-deficient nerve terminals -- Neuroprotection by lowering cholesterol |
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880-01/(S Machine generated contents note: 1. Presynaptic Glutamate Transport in the Brain -- References -- 2. Cholesterol and Its Role in Synaptic Transmission -- References -- 3. Effects of Cholesterol-Depleting Agent Methyl-β-Cyclodextrin on the Functional State of Brain Nerve Terminals -- 3.1. Extraction of Cholesterol from Brain Nerve Terminals by MβCD, Confocal Imaging and Flow Cytometric Analysis of Cholesterol-Deficient Nerve Terminals -- 3.2. Effects of MβCD on the Proton Gradient of Synaptic Vesicles -- References -- 4. Extracellular Level and Uptake of Glutamate in Cholesterol-Deficient Nerve Terminals -- 4.1. Effects of Acute and Long-Term Treatment of the Synaptosomes with MβCD on Glutamate Uptake -- 4.2. Extracellular Glutamate Level After Cholesterol Depletion -- References -- 5. Unstimulated and Exocytotic Glutamate Release from Cholesterol-Deficient Nerve Terminals -- 5.1. Tonic (Unstimulated) Release of Glutamate from Cholesterol-Depleted Synaptosomes -- 5.2. Influence of the Continuous Enrichment of the Cytoplasm with Vesicular Glutamate on Tonic Release of the Neuromediator -- 5.3. Leakage of Glutamate from Cholesterol-Deficient Nerve Terminals at Low Temperature -- 5.4. Exocytotic Release of Glutamate During Acute and Long-Term Treatment of the Synaptosomes with MβCD -- References -- 6. Neuroprotection by Lowering Cholesterol -- 6.1. Stimulated by Depolarization of the Plasma Membrane Transporter-Mediated Release of Glutamate from Cholesterol-Deficient Nerve Terminals -- 6.2. Release of Glutamate from Cholesterol-Deficient Nerve Terminals by Means of Heteroexchange -- 6.3. Release of Glutamate in Low-Na+ Medium from Cholesterol-Deficient Nerve Terminals -- 6.4. Transporter-Mediated Release of Glutamate from Cholesterol-Deficient Nerve Terminals During Dissipation of the Proton Gradient of Synaptic Vesicles -- 6.5. Transporter-Mediated Release of Glutamate from Cholesterol-Deficient Nerve Terminals Under Conditions of Energy Deprivation -- References |
| Summary |
Glutamate is the primary excitatory neurotransmitter in the CNS and disturbances in glutamate transport contribute to a number of neurological and neurodegenerative disorders. Appropriate levels of cholesterol are very important for the proper functioning of glutamate transport while unbalanced levels of cholesterol have been implicated in the pathogenesis of disorders such as stroke, ischemia, traumatic brain injury, and neurotoxicity. In the proposed book, the author presents data from the literature and from her own lab to address the extent to and way in which membrane cholesterol modulates presynaptic glutamate transport and whether lowering the level of cholesterol available can offer some neuroprotective benefits |
| Analysis |
Medicine |
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Neurosciences |
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Neurochemistry |
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Biomedicine |
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biomedische wetenschappen |
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neurochemie |
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neurowetenschap |
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neuroscience |
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Medicine (General) |
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Geneeskunde (algemeen) |
| Bibliography |
Includes bibliographical references |
| Notes |
Online resource; title from PDF title page (SpringerLink, viewed July 17, 2013) |
| Subject |
Neurobiology.
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Neurotransmitters.
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Cholesterol -- Physiological effect
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Neural transmission.
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Cholesterol -- physiology
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Glutamates -- physiology
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Synaptic Transmission
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Neurobiology
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Neurotransmitter Agents
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SOCIAL SCIENCE -- Anthropology -- Physical.
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Cholesterol -- Physiological effect.
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Neurobiology.
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Neurotransmitters.
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| Form |
Electronic book
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| ISBN |
9781461477594 |
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146147759X |
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1461477581 |
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9781461477587 |
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