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Title Growth hormone therapy in pediatrics : 20 years of KIGS / editors, Michael B. Ranke, David A. Price, Edward O. Reiter
Published Basel ; New York : Karger, ©2007


Description 1 online resource (xvi, 519 pages) : illustrations
Contents Cover; Contents; Contributors; Preface; 1 KIGS; KIGS: Structure and Organization; Background; Scientific Organization; Reporting of Data in KIGS; The KIGS Database; Data Management; Data Collection; Quality Control; Data Processing; The Future; References; 2 Review; Assessment of Growth and Puberty; Growth References; Use of Growth Charts; Inherent and Unresolved Problems of Growth Charts; Disease-Specific Growth Charts; Height Velocity Assessment and Calculation; Further Discussion of Analyses of Growth during Puberty; The Age of the Onset of Puberty
Determination of the Clinical Onset of PubertyPubertal Growth in Late Maturers and Short Individuals; Prediction of Adult Height; Target Height; The Use of Bone Age to Predict Adult Height; Predicting Adult Height in Children with Disability; Conclusions; References; 3 KIGS; Diagnosis of Children with Short Stature: Insights from KIGS; Methods; Results; Idiopathic GHD; Organic GHD; Other Causes of Short Stature; Discussion; Conclusions; References; 4 KIGS; Data Analyses within KIGS; Anthropometrical Standards in Healthy Children; Size at Birth; Body Mass Index; Height Velocity; Puberty Onset
Near Adult HeightBone Age; Body Surface Area; Target Height; Disease-Specific References; Data Analysis; Means and SD versus Medians and Centiles; Standard Deviation Scores; Group Comparison; Missing Data; GH Dose ; Computer Programmes; References; 5 KIGS; The KIGS Aetiology Classification System; Underlying Philosophy of the KIGS Aetiology Classification List; Hierarchy of Diagnoses; Chromosomal, Molecular Genetic or Biochemical Definitions; Growth Hormone Deficiency; KIGS Aetiology Classification List No. 1.1 ff.: Idiopathic Growth Hormone Deficiency
KIGS Aetiology Classification List No. 1.2 ff.: Neurosecretory DysfunctionKIGS Aetiology Classification List No. 2.1.5: Bioinactive Growth Hormone Syndrome; KIGS Aetiology Classification List No. 3.1: Idiopathic Short Stature; KIGS Aetiology Classification List No. 3.2.1-3.3.9; KIGS Aetiology Classification List No. 3.4 ff. and 3.5 ff.: Intrauterine Growth Retardation; KIGS Aetiology Classification List No. 3.6 ff.: Skeletal Dysplasias; KIGS Aetiology Classification List No. 3.8 ff.: Disorders in Specific Systems; KIGS Aetiology Classification List No. 3.12 ff.: Psychogenic Short Stature
Concluding RemarksKIGS Aetiology Classification List; References; 6 Review; Growth Hormone Deficiency: Growth Hormone Tests and Growth Hormone Measurements; Historical Context; Diagnosis of Growth Hormone Deficiency; Growth Hormone Measurements and Growth Hormone Stimulation Tests; Standardization of Growth Hormone Assays; Spontaneous Growth Hormone Secretion; Growth Hormone-Releasing Hormone Tests and Combinations; Limitations of Testing; Testing Limitations in Special Situations; References; 6 KIGS; Growth Hormone Testing in KIGS; Patients and Methods; Results
Summary For 20 years, KIGS (Pfizer International Growth Database) has provided an outstanding tool for monitoring the use, efficacy and safety of growth hormone (GH) treatment in children with short stature of varying origin. This volume offers a comprehensive update of the continuing experiences in KIGS and is based on data from more than 50 countries and more than 60,000 patients. International experts analyse in detail the basic auxological characteristics of patients and their response to GH treatment for a broad spectrum of growth disorders. These include idiopathic GH deficiency, organic GH deficiency due to a variety of causes such as congenital malformations and syndromes, genetic disorders or treatment for leukaemia or central nervous system tumours and short stature in children born small for gestational age, specific syndromes and systemic disorders. Each growth disorder is also covered by a review of relevant published data by international experts. KIGS has also established itself as a primary source of information about adverse events during long-term GH treatment in children. The recent analysis of KIGS data has revealed no new adverse drug reactions since the 10-year follow-up. Therefore, treatment with GH seems a low-risk intervention inchildren and adolescents with various growth disorders. The process of developing disease-specific growth response prediction models has been ongoing in KIGS for many years. The available models are accurate, precise and have a relatively high degree of predictive power, although further predictors of the growth response remain to be identified. The KIGS prediction models can be applied prospectively to new patients, enabling their GH therapy to be better tailored and monitored to achieve optimal growth, safety and cost outcomes. The future of KIGS within the era of evidence-based medicine will continue to depend upon the quality of the data reported. Therefore, the commitment of participating physicians will continue to be a decisive element. The ongoing recognition of the importance of valid safety and efficacy information in the practice of paediatric endocrinology is exemplified by this valuable international collaboration of clinicians and the pharmaceutical community
Bibliography Includes bibliographical references and indexes
Notes Print version record
SUBJECT Pharmacia & Upjohn International Growth Database
Subject Dwarfism, Pituitary -- Hormone therapy
Growth hormone releasing factor -- Physiological effect
Longitudinal method.
Growth Disorders -- drug therapy
Databases, Factual
Growth Hormone -- therapeutic use
Longitudinal Studies
children (people by age group)
Longitudinal method
Kind -- Krankheit -- Somatotropin -- Aufsatzsammlung.
Somatotropin -- Kind -- Krankheit -- Aufsatzsammlung.
Form Electronic book
Author Ranke, Michael B
Price, David A. (David Anthony), 1943-
Reiter, Edward O
S. Karger (Firm)
ISBN 9783318014471