Description |
1 online resource (xiii, 506 pages, 16 unnumbered pages of plates) : illustrations (some color) |
Series |
Wiley series on drug discovery and development |
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Wiley series in drug discovery and development.
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Contents |
HIV-1 INTEGRASE: Mechanism and Inhibitor Design; CONTENTS; PREFACE; CONTRIBUTORS; 1 HIV Life Cycle: Targets for Anti-HIV Agents; 2 pp32 Is Hot; 3 Integrase Mechanism and Function; 4 Structural Studies of Retroviral Integrases; 5 Retroviral Integration Target Site Selection; 6 Pleiotropic Nature of HIV-1 Integrase Mutations; 7 Insights into HIV-1 Integrase-DNA Interactions; 8 Functional Interaction Between Human Immunodeficiency Virus Type 1 Reverse Transcriptase and Integrase; 9 Cellular Cofactors of HIV Integration; 10 Structural Aspects of Lentiviral Integrase-LEDGF Interaction |
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11 Host Factors that Affect Provirus Stability and Silencing12 Assays for Evaluation of HIV-1 Integrase Enzymatic Activity, DNA Binding, and Cofactor Interaction; 13 HIV-1 Integrase Inhibitor Design: Overview and Historical Perspectives; 14 HIV Integrase Inhibitors: From Diketo Acids to Heterocyclic Templates: History of HIV Integrase Medicinal Chemistry at Merck West Point and Merck Rome (IRBM) Leading to Discovery of Raltegravir; 15 Elvitegravir: Novel Quinolone HIV-1 Integrase Strand Transfer Inhibitor; 16 Conformationally Constrained Tricyclic HIV Integrase Inhibitors |
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17 Slow-Onset Kinetics of HIV Integrase Inhibitors and Proposed Molecular Model18 Azaindole Hydroxamic Acids Are HIV-1 Integrase Inhibitors; 19 Simple and Accurate In Vitro Method for Predicting Serum Protein Binding of HIV Integrase Strand Transfer Inhibitors; 20 Role of Metals in HIV-1 Integrase Inhibitor Design; 21 Discovery and Development of Natural Product Inhibitors of HIV-1 Integrase; 22 Development of Styrylquinoline Integrase Inhibitors; 23 Dicaffeoyltartaric Acid and Dicaffeoylquinic Acid HIV Integrase Inhibitors; 24 Design and Discovery of Peptide-Based HIV-1 Integrase Inhibitors |
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25 Nucleotide-Based Inhibitors of HIV Integrase26 Computer-Aided Techniques in Design of HIV-1 Integrase Inhibitors; 27 Application of Protein Covalent Modification to Studying Structure and Function of HIV-1 Integrase and Its Inhibitors; 28 HIV-1 Integrase-DNA Models; 29 New Paradigm for Integrase Inhibition: Blocking Enzyme Function Without Directly Targeting the Active Site; 30 Resistance to Inhibitors of HIV-1 Integrase; INDEX; Colour Plates; Wiley Series in Drug Discovery and Development |
Summary |
This book comprehensively covers the mechanisms of action and inhibitor design for HIV-1 integrase. It serves as a resource for scientists facing challenging drug design issues and researchers in antiviral drug discovery. Despite numerous review articles and isolated book chapters dealing with HIV-1 integrase, there has not been a single source for those working to devise anti-AIDS drugs against this promising target. But this book fills that gap and offers a valuable introduction to the field for the interdisciplinary scientists who will need to work together to design drugs that target HIV-1 |
Bibliography |
Includes bibliographical references and index |
Notes |
English |
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Print version record |
Subject |
HIV (Viruses) -- Enzymes.
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HIV (Viruses) -- Enzymes -- Inhibitors
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Antiviral agents.
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Drugs -- Design.
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HIV Integrase Inhibitors -- pharmacology
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Drug Design
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HIV Integrase
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Antiviral Agents
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HEALTH & FITNESS -- Diseases -- AIDS & HIV.
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MEDICAL -- AIDS & HIV.
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Drugs -- Design
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Antiviral agents
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HIV (Viruses) -- Enzymes
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Form |
Electronic book
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Author |
Neamati, Nouri.
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LC no. |
2010043285 |
ISBN |
9781118015377 |
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1118015371 |
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9781118015353 |
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1118015355 |
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1118015363 |
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9781118015360 |
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