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Author Shallal, Mohammed Jasim Mohammed, author

Title Recombinant influenza viruses as a vaccine vector for HIV / by Mohammed Jasim Mohammed Shallal
Published 2015


Location Call no. Vol. Availability
 W'PONDS  615.372 Sha/Riv  AVAILABLE
Description 1 CD-ROM (PDF file (xvii, 217 pages : illustrations) ; 12 cm
4 3/4 in
Summary Live recombinant influenza viruses were successfully used as HIV vaccine vectors in a mouse model. Following intranasal prime-boost vaccination, HIV-specific CD8+ T cell responses were detected in the spleen, broncho-alveolar lavage, mediastinal and inguinal lymph nodes. HIV+α4β7+ CD8+ T cells contributed to protection in pseudo-challenge experiments using recombinant vaccinia virus expressing HIV antigens. This research highlights the importance of mucosal CD8+ T cells in viral immunity and emphasizes the need for additional studies to provide key insights to underpin future vaccine development
Notes Submitted to the School of medicine in the Faculty of Health, Deakin University
Thesis (Ph.D.) -- Deakin University, Victoria, 2015
Bibliography Bibliography: 160-210 pages
Subject AIDS vaccines.
HIV antibodies.
Influenza viruses.
Genre/Form Academic theses.
Author Deakin University. Faculty of Health
Deakin University. School of Medicine, degree granting institution