| Description |
1 CD-ROM (PDF file (xvii, 217 pages : illustrations) ; 12 cm |
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4 3/4 in |
| Summary |
Live recombinant influenza viruses were successfully used as HIV vaccine vectors in a mouse model. Following intranasal prime-boost vaccination, HIV-specific CD8+ T cell responses were detected in the spleen, broncho-alveolar lavage, mediastinal and inguinal lymph nodes. HIV+α4β7+ CD8+ T cells contributed to protection in pseudo-challenge experiments using recombinant vaccinia virus expressing HIV antigens. This research highlights the importance of mucosal CD8+ T cells in viral immunity and emphasizes the need for additional studies to provide key insights to underpin future vaccine development |
| Notes |
Submitted to the School of medicine in the Faculty of Health, Deakin University |
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Thesis (Ph.D.) -- Deakin University, Victoria, 2015 |
| Bibliography |
Bibliography: 160-210 pages |
| Subject |
AIDS vaccines.
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HIV antibodies.
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Influenza viruses.
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| Genre/Form |
Academic theses.
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| Author |
Deakin University. Faculty of Health
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Deakin University. School of Medicine, degree granting institution
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