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Title Current research in head and neck cancer : molecular pathways, novel therapeutic targets, and prognostic factors / volume editor, Henning Bier
Published Basel ; New York : Karger, ©2005


Description 1 online resource (vi, 207 pages) : illustrations
Series Advances in oto-rhino-laryngology, 0065-3071 ; v. 62
Advances in oto-rhino-laryngology ; v. 62. 0065-3071
Contents Development of a conditional mouse model for head and neck squamous cell carcinoma / Bindels, E.M.J., van de Brekel, M.W.M. -- Hypofolatemia as a risk factor for head and neck cancer / Almadori, G. [and others] -- Reduced DNA repair capacity in laryngeal cancer subjects: a comparison of phenotypic and genotypic results / Gajacka, M. [and others] -- Intratumoral genomic heterogeneity in advanced head and neck cancer detected by comparative genomic hybridization / Götte, K. [and others] -- Function and importance of p63 in normal oral mucosa and squamous cell carcinoma of the head and neck / Thurfjell, N. [and others] -- p53, p63 and p73 expression in squamous cell carcinomas of the head and neck and their response to cisplatin exposure / Balz, V. [and others]
Expression of p16 protein is associated with human papillomavirus status in tonsillar carcinomas and has implications on survival / Wittekindt, C. [and others] -- EGFR-antibody-supplemented TPF chemotherapy: preclinical investigations to a novel approach for head and neck cancer induction treatment / Knecht, R. [and others] -- Nuclear factor kappa B as a common target and activator of oncogenes in head and neck squamous cell carcinoma / Chang, A.A., Van Waes, C. -- Antiangiogenic therapy of head and neck squamous cell carcinoma by vascular endothelial growth factor antisense therapy / Riedel, F. [and others] -- Expression pattern of chemokine receptors 6 and 7 in squamous cell carcinoma of the head and neck identifies a novel metastatic phenotype / Wang, J. [and others] -- p53-based immunotherapy of cancer / De Leo, A.B
p53 as an immunotherapeutic target in head and neck cancer: approaches to reversing unresponsiveness of T lymphocytes and preventing tumor escape / Hoffmann, T.K. [and others] -- Imbalance in absolute counts of T lymphocyte subsets in patients with head and neck cancer and its relation to disease / Kuss, I. [and others] -- Antitumor immunization of head and neck squamous cell carcinoma patients with a virus-modified autologous tumor cell vaccine / Herold-Mende, C. [and others] -- Prognostic factors: confusion caused by bad quality of design, analysis and reporting of many studies / Sauerbrei, W
Summary The development of head and neck cancer is a multistep process in which genetic as well as epigenetic alterations interfere with the regular functions of proto-oncogenes and tumor suppressor genes. In addition, carcinogenesis is promoted by the impairment of mechanisms responsible for the maintenance of genetic stability. The accumulation of crucial events such as evasion of apoptosis, lack of senescence, deregulated proliferation, invasion and metastasis, as well as neoangiogenesis eventually determines the malignant phenotype. The 16 articles of this volume span from advances in the understanding of underlying molecular pathways (conditional mouse model, folate activity, DNA repair, genomic heterogeneity, p53 family members, human papillomavirus), to preclinical and clinical studies investigating potential novel therapeutic targets (epidermal growth factor receptor, nuclear factor-kappaB, vascular endothelial growth factor, chemokine receptors, P53-based immunotherapy, virus-modified tumor vaccination), and biometric considerations on the evaluation of prognostic factors. This state-of-the-art publication is recommended reading not only for ENT specialists and oncologists, but also for molecular biologists and other subspecialists interested in head and neck cancer research
Bibliography Includes bibliographical references and index
Notes Master and use copy. Digital master created according to Benchmark for Faithful Digital Reproductions of Monographs and Serials, Version 1. Digital Library Federation, December 2002. MiAaHDL
digitized 2010 HathiTrust Digital Library committed to preserve pda MiAaHDL
Print version record
Subject Head -- Cancer.
Neck -- Cancer.
Head and Neck Neoplasms -- genetics
Genes, Tumor Suppressor
Head and Neck Neoplasms -- therapy
Head -- Cancer
Neck -- Cancer
Kopfregion -- Krebs <Medizin> -- Aufsatzsammlung.
Krebs <Medizin> -- Kopfregion -- Aufsatzsammlung.
Halsregion -- Krebs <Medizin> -- Aufsatzsammlung.
Krebs <Medizin> -- Halsregion -- Aufsatzsammlung.
Form Electronic book
Author Bier, Henning
ISBN 9783318011197