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Title Innovative drug development for headache disorders / edited by Jes Olesen, Nabih Ramadan
Published Oxford ; New York : Oxford University Press, 2008


Description 1 online resource (xii, 227 pages) : illustrations
Series Frontiers in headache research series ; v. 16
Frontiers in headache research ; v. 16.
Contents Effectiveness of different steroid dosage in Tolosa-Hunt syndrome with different phenotypes: some critical points about the new International Headache Society classification / E. Marchioni [and others] -- Discussion summary: trial methodology / Jes Olesen -- Inducible nitric oxide synthase and development of new migraine treatments / Boris A. Chizh -- Mechanisms of cortical spreading depression as targets for migraine therapy / Kevin C. Brennan and Andrew C. Charles -- Tonabersat / Peter R. Blower and Paul C. Sharpe -- Discussion summary: nitric oxide and spreading depression modulators / Nabih Ramadan -- Calcitonin gene-related peptide: relevance for migraine / Jes Olesen and Inger Jansen-Olesen
KATP channels and migraine / Inger Jansen-Olesen and Kenneth Beri Ploug -- Antiepileptic drugs and migraine / Michael A. Rogawski -- Discussion summary : ion channel modulators and antiepileptics / Pramod R. Saxena -- Innovative drug development for headache disorders : glutamate / Kirk W. Johnson [and others] -- The modulation of TRPV1 channels by cannabinoid1 receptors / Beatriz Fioravanti and Todd W. Vanderah -- Future targets for headache therapy: prostanoids / Christian Waeber -- Role of anandamide in the modulation of nitroglycerin-induced hyperalgesia: a study in the rat / Cristina Tassorelli [and others]
Summary Migraine treatment improved considerably with the advent of the 'triptans' in the 1990s. While the drugs used previously for headache treatment had efficacy, some compounds had bothersome side effects and their overuse could lead to severe complications. In the early days of the triptans, it was widely presumed that migraine was no longer a treatment problem. However, it has gradually been recognized that a significant proportion of patients are not responsive to triptans or do not tolerate them
Bibliography Includes bibliographical references and index
Notes Print version record
Subject Headache -- Chemotherapy
Drug development.
Headache Disorders -- drug therapy
Headache Disorders -- prevention & control
HEALTH & FITNESS -- Diseases -- Nervous System (incl. Brain)
MEDICAL -- Neurology.
Drug development.
Headache -- Chemotherapy.
Céphalées -- traitement médicamenteux.
Céphalées -- prévention et contrôle.
Migraine -- Chimiothérapie.
Form Electronic book
Author Olesen, Jes
Ramadan, Nabih
LC no. 2008021573
ISBN 9780191564628