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Title Transfusion medicine and hemostasis : clinical and laboratory aspects / edited by Christopher D. Hillyer [and others]
Published Amsterdam ; Boston : Elsevier, ©2009


Description 1 online resource (xxiii, 775 pages) : illustrations
Contents Part I. Blood banding and transfusion medicine -- Blood banding and transfusion medicine: the field, the discipline and the industry -- Brief history of blood transfusion -- Introduction to quality systems and quality management -- The role of the physician in the blood center-- The blood donor, donation process and technical aspects of blood collection -- Apheresis blood component collections -- Recipient-specific blood donations -- Adverse donor reactions -- Component preparation and manufacturing -- Serologic testing of donor products -- Overview of infectious disease testing -- HIV screening of donor products -- Hepatitis B screening of donor products -- Hepatitis C screening of donor products -- West Nile virus screening of donor products -- Syphilis, HTLV and Chagas testing of donor products -- Bacterial detection methods -- The role of the transfusion service physician -- Pretransfusion testing -- Antibody identification -- Direct antiglobulin test -- ABO and H blood group system -- Rh blood group system -- Kell and Kidd blood group systems -- MNS and Duffy blood group systems -- Lewis I and P blood group systems -- Other blood group systems, collections and antigens -- Red blood cells and related products -- Plasma products -- Platelet products -- Cryoprecipitate -- Granulocyte products -- Albumin and related products -- Human immunoglobulin preparations -- Rh immune globulin -- Irradiation of blood products -- Leukoreduction of blood products -- CMV-safe blood products -- Frozen blood products -- Washed blood products -- Volume-reduced products -- Neonatal and pediatric transfusion medicine -- Perinatal transfusion medicine -- Autoimmune hemolytic anemias -- Transfusion management in patients with hemoglobinopathies -- Transfusion of patients undergoing HPC and solid-organ transplantation -- Transfusion of HIV-positive patients -- Management of patients who refuse blood transfusion --Platelet transfusion refractory patients -- Massive transfusion -- Perioperative blood management -- Adverse events and outcomes following transfusion: an overview -- Febrile non-hemolytic transfusion reactions -- Allergic, anaphylactoid and anaphylactic reactions -- Delayed hemolytic transfusion reactions -- Transfusion-associated circulatory overload -- Transfusion-related acute lung injury -- Septic transfusion reactions -- Metabolic, hypotensive and other acute reactions and complications -- Posttransfusion purpura -- Transfusion associated graft versus host disease -- Microchimerism -- Transfusion related immunomodulation -- Iron overload -- Transfusion transmitted diseases -- Overview of therapeutic apheresis -- Therapeutic plasma exchange -- Therapeutic erythrocytapheresis -- Therapeutic thrombocytapheresis -- Therapeutic leukapheresis -- Extracorporeal photopheresis -- LDL pheresis -- Immunoadsorption -- Therapeutic phlebotomy -- HPC products -- Tissue banking in the hospital setting
Part II. Coagulation -- Overview of the coagulation system -- Approach to the bleeding patient -- Congenital thrombocytopenia -- Neonatal alloimmune thrombocytopenia -- Acquired neonatal thrombocytopenia -- Bernard-Soulier syndrome and other GPIb-IX-V related receptor defects -- Glanzmann thrombasthenia -- Platelet storage-granule defects -- Failure to release and aspirin-like defects -- Acute (childhood) immune thrombocytopenic purpura -- Chronic immune thrombocytopenic purpura -- Drug-induced thrombocytopenia -- Heparin-induced thrombocytopenia -- autoimmune lymphoproliferative syndrome -- Hemolytic uremic syndrome -- Thrombotic thrombocytopenic purpura -- Antiphospholipid antibody syndrome -- von Willebrand disease -- Hemophilia A -- Hemophilia B -- Congenital disorders of fibrinogen -- Factor XIII, [alpha][2]-antiplasmin and plasminogen activator inhibitor-1 deficiencies -- Factor XI deficiency -- Factor VII deficiency -- Factor II, factor V and factor X deficiencies -- Bleeding disorders in pregnancy -- Vascular bleeding disorders -- Bleedings risks with liver disease -- Bleeding risks with vitamin K deficiency -- Bleeding risks with cardiac disease -- Bleeding risks with renal disease -- Bleeding risks in cancer -- Disseminate intravascular coagulopathy -- Acquired coagulation factor inhibitors -- Introduction to coagulation testing -- Prothrombin time and activated partial thromboplastin time -- Platelet count -- Global tests of primary hemostasis -- Platelet aggregation studies -- Laboratory diagnosis of genetic platelet function defects -- Laboratory diagnosis of acquired platelet function defects -- Laboratory diagnosis of immune thrombocytopenic purpura -- ADAMTS13 testing -- Laboratory diagnosis of heparin-induced thrombocytopenia -- Molecular biology of von Willebrand disease -- Laboratory diagnosis of inherited von Willebrand disease -- Laboratory diagnosis of acquired von Willebrand syndrome -- Laboratory assessment of treatment of von Willebrand disease -- Coagulation factor testing -- Mixing studies -- Specific factor inhibitor testing -- Laboratory diagnosis of dysfibrinogenemia and afibrinogenemia -- Laboratory assessment of fibrinolysis -- General overview of the hypercoagulable state -- Antithrombin testing -- Proteins C, S and Z testing -- Activated protein C resistance and factor V Leiden testing -- Prothrombin gene mutation testing -- Laboratory diagnosis of hyperhomocysteinemia -- Laboratory diagnosis of lupus anticoagulant and antiphospholipid antibodies -- Lipoproteins(a) testing -- Laboratory diagnosis of factor level abnormalities associated with thrombosis -- Laboratory management of DIC -- Laboratory support for heparin monitoring -- Laboratory support for Warfarin monitoring -- Prothrombin complex concentrates -- von Willebrand factor concentrates -- Factor VIII concentrates -- Factor IX concentrates -- Factor VII concentrates -- Antithrombin concentrates -- Protein C concentrates
Summary This new handbook in transfusion medicine and hemostasis aims to combine clinical and laboratory information from two fields which have high degrees of overlap into one concise, easy-to-use pocket book. This comprehensive reference guide will have the depth of information to be helpful to all physicians who order and administer blood components and specialized factors for hemostatic abnormalities, as well as those who consult and care for these often very ill patients. The breadth of the book will be ideal for pathology, transfusion medicine, hematology, and anesthesiology residents and fellows, as well as certified and specialized practitioners in these fields. The editors have chosen to employ a standardized format throughout the book which allows each chapter to be focused on a well-defined subject consisting of less than 6 pages. Information should be easy to read, precise, and concise. Though extensive reference lists are valuable in larger texts, they are not necessary in a pocket-size handbook intended for quick reference. The editors have chosen to include key, recent publications as "Further Readings", most often from the past 2 years. A general reference list to larger textbooks and standards in the fields will be included at the end along with a list of common abbreviations and indexes that cross reference diagnostic, clinical and therapeutic commonalities
Bibliography Includes bibliographical references and index
Notes English
Print version record
Subject Blood -- Transfusion.
Blood -- Collection and preservation.
Blood -- Diseases.
Biological products -- Therapeutic use.
Health facilities.
Medical care.
Hematologic Diseases
Hematologic Tests
Biological Specimen Banks
Laboratory Techniques and Procedures
Biological Therapy
Blood Physiological Phenomena
Hemic and Lymphatic Diseases
Health Facilities
Health Care Facilities, Manpower, and Services
Analytical, Diagnostic and Therapeutic Techniques and Equipment
Circulatory and Respiratory Physiological Phenomena
Delivery of Health Care
Phenomena and Processes
Blood Transfusion
Blood Transfusion [MESH]
Blood Preservation
Blood Banks
Hematologic Diseases -- therapy
Hematologic Tests -- methods
Blood Banks [MESH]
Hematologic Diseases -- therapy [mesh]
Hematologic Tests -- methods [mesh]
Hemostasis [MESH]
Patient Care
health facilities.
treating (health care function)
MEDICAL -- Pharmacology.
Medical care
Health facilities
Blood -- Diseases
Biological products -- Therapeutic use
Blood -- Collection and preservation
Blood -- Transfusion
Form Electronic book
Author Hillyer, Christopher D.
ISBN 9780123744326