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Title High-throughput lead optimization in drug discovery / edited by Tushar Kshirsagar
Published Boca Raton : CRC Press, ©2008


Description 1 online resource (ix, 243 pages) : illustrations
Series Critical reviews in combinatorial chemistry
Critical reviews in combinatorial chemistry.
Contents Application of parallel synthesis to the optimization of inhibitors of the ZipA-FtsZ protein-protein interaction / Lee D. Jennings -- Case studies of parallel synthesis in hit identification, hit exploration, hit-to-lead, and lead optimization programs / Alexander Ernst and Daniel Obrecht -- A successful application of parallel synthesis to computer-assisted structural optimization of new leads targeting human immunodeficiency virus-1 reverse transcriptase : the case of acylthiocarbamates and thiocarbamates / Angelo Ranise, Andrea Spallarossa, and Sara Cesarmni -- How high-throughput medicinal chemistry can expedite lead discovery, lead optimization, and beyond / Rongshi Li -- Rapid lead identification of inhibitors of adenine nucleotide translocase : a case study of applying combinatorial chemistry techniques in drug discovery / Yazhong Pei, Walter H. Moos, and Soumitra Ghosh -- Parallel synthesis of anticancer, antiinflammatory, and antiviral agents derived from L- and D-amino acids / Robert C. Reid and David P. Fairlie -- Application of solid-phase parallel synthesis in lead optimization studies / Bijoy Kundu -- High-throughput solid-phase synthesis of nucleoside-based libraries in the search for new antibiotics / Dianqing Sun and Richard E. Lee
Summary Describes the application of parallel synthesis towards lead optimization as well as the design and synthesis of targeted libraries. This book reflects the shift toward conducting parallel lead optimization in-house while outsourcing most of the screening libraries synthesis
Bibliography Includes bibliographical references and index
Notes Print version record
Subject High throughput screening (Drug development)
Combinatorial chemistry.
Drug development.
Drugs -- Design.
Gene libraries.
Combinatorial Chemistry Techniques
Drug Design
Databases, Genetic
Gene Library
Genomic Library
MEDICAL -- Drug Guides.
MEDICAL -- Pharmacology.
MEDICAL -- Pharmacy.
MEDICAL -- Nursing -- Pharmacology.
Gene libraries
Drugs -- Design
Combinatorial chemistry
Drug development
High throughput screening (Drug development)
High throughput screening
Kombinatorische Synthese
Form Electronic book
Author Kshirsagar, Tushar.
ISBN 9781420006964