| Description |
1 online resource (vii, 246 pages) : illustrations (some color) |
| Series |
Genome dynamics, 1660-9263 ; v. 1 |
|
Genome dynamics ; v. 1. 1660-9263
|
| Contents |
The genomic basis of disease, mechanisms and assays for genomic disorders / P. Stankiewicz, J.R. Lupski -- Gross deletions and translocations in human genetic disease / S.S. Abeysinghe, N. Chuzhanova, D.N. Cooper -- Nucleotide excision repair and related human diseases / V. Bergoglio, T. Magnaldo -- Oxidative damage to DNA in non-malignant disease / M.D. Evans, M.S. Cooke -- Dominant non-coding repeat expansions in human disease / K.A. Dick [and others] -- Telomeres and telomerase in stem cells during aging and disease / Z. Ju, K.L. Rudolph -- Retrotransposable elements and human disease / P.A. Callinan, M.A. Batzer -- The spindle checkpoint and chromosomal stability / W. Qi, H. Yu -- Protein kinases that regulate chromosome stability and their downstream targets / H. Nojima -- The role of the APC tumor suppressor in chromosomal instability / P. Alberici, R. Fodde -- c-Myc, genomic instability, and disease -- F. Kuttler, S. Mai -- Nijmegen breakage syndrome and functions of the responsible protein, NBS1 / A. Antoccia [and others] -- Werner syndrome, aging, and cancer / A. Ozgenc, L.A. Loeb -- Fanconi anemia / R. Kalb [and others] |
| Summary |
Cancer and other genetic human diseases are caused by a variety of mutations, ranging from subtle sequence changes to larger genomic rearrangements and alterations in chromosome number (aneuploidy). With contributions by reputed experts, this book aims to update the knowledge on the multiple mechanisms of genomic instability leading to human disease. Emphasis is given to the different types of genomic sequences involved in disease-related genomic rearrangements as well as to the various exogenous factors increasing the frequency of mutations. Several chapters are dedicated to the dysfunction o |
| Bibliography |
Includes bibliographical references and indexes |
| Notes |
Print version record |
| Subject |
Genetic disorders.
|
|
Medical genetics.
|
|
Genomes.
|
|
Genetic Diseases, Inborn
|
|
Genome
|
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Genetics, Medical
|
|
Genomic Instability
|
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HEALTH & FITNESS -- Diseases -- Genetic.
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MEDICAL -- Genetics.
|
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Genetic disorders
|
|
Genomes
|
|
Medical genetics
|
|
Genom -- Humangenetik -- Aufsatzsammlung.
|
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Humangenetik -- Genom -- Aufsatzsammlung.
|
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Erbkrankheit -- Aufsatzsammlung.
|
| Form |
Electronic book
|
| Author |
Volff, Jean-Nicolas
|
| ISBN |
1423796896 |
|
9781423796893 |
|
9783318012903 |
|
3318012904 |
|
9783805580298 |
|
3805580290 |
|
