| Description |
1 online resource |
| Contents |
Front Matter -- Novel Anti-Inflammatory Drugs Based on Targeting Lung Dendritic Cells and Airway Epithelial Cells / Bart N Lambrecht, Maud Plantinga, Monique Willart, Hamida Hammad -- Role of Th2 Cells in the Allergic Diathesis / Marsha Wills-karp -- Cells Contributing to the Pathogenesis of Allergic Diseases in the Respiratory Tract. Importance of Th17- and Th1-Associated Responses for the Development of Asthma / Tomohiro Yoshimoto, Hiroko Tsutsui, Kenji Nakanishi -- Regulatory T Cells / Chris Corrigan, Kimuli Ryanna -- A Role for Natural Killer T-Cell Subsets in the Pathogenesis of Various Allergic Disorders / Hiroshi Watarai, Michishige Harada, Mayumi Tamari, Masaru Taniguchi -- Regulatory Roles of B Cells in Allergy and Inflammation / Kiyoshi Takatsu, Masashi Ikutani, Yoshinori Nagai -- Mast Cells / Mindy Tsai, Stephen J Galli -- Eosinophils / Nancy A Lee, Mark V Dahl, Elizabeth A Jacobsen, Sergei I Ochkur -- Basophils in Inflammation and Allergy Drug Design / Donald MacGlashan -- Epithelial Cells / Tillie-Louise Hackett, Stephanie Warner, Dorota Stefanowicz, Darryl Knight -- Fibroblasts / Alastair G Stewart, Lilian Soon, Michael Schuliga -- Airway Smooth Muscle Cells / Andrew J Halayko, Pawan Sharma -- Cytokines Contributing to the Pathogenesis of Allergic Diseases in the Respiratory Tract. Interleukin 4, Interleukin 13, and Interleukin 9 / Kenji Izuhara, Shoichiro Ohta, Hiroshi Shiraishi, Shoichi Suzuki -- Interleukin 3, Interleukin 5, and Granulocyte₆Macrophage Colony-Stimulating Factor / Alba Llop-Guevara, Josip Marcinko, Ramzi Fattouh, Manel Jordana -- Interleukin 15, Interleukin 17, and Interleukin 25 / Hiroshi Nakajima, Itsuo Iwamoto -- Thymic Stromal Lymphopoietin / Kazuhiko Arima, Yong-Jun Liu -- Interleukin 10 / Whitney W Stevens, Larry Borish, John W Steinke -- Tumor Necrosis Factor Alpha / Christopher Brightling, Latifa Chachi, Dhan Desai, Yassine Amrani -- Profibrotic and Angiogenic Factors in Asthma / Neville Berkman, Francesca Levi-Schaffer -- Chemokines / Luis M Teran, Juan R Velazquez -- Epithelial Growth Factors / Yasuhiro Gon, Shu Hashimoto -- Other Mediators Contributing to the Pathogenesis of Allergic Diseases in the Respiratory Tract. Prostanoids / Sarah A Maher, Deborah L Clarke, Maria G Belvisi -- Leukotrienes / Katsuhide Okunishi, Marc Peters-Golden -- Proteases in Allergy / Keisuke Oboki, Hirohisa Saito -- Toll-Like Receptors / Jessica L Allen, Aurelien Trompette, Christopher L Karp -- Index |
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Novel anti-inflammatory drugs based on targeting lung dentritic cells and airway apithelial cells / Bart Lambrecht [and others] -- Th2 cells / Marsha Wills-Karp -- Importance of Th17 and Th1-associated responses for the development of asthma / Yoshimoto Tomohiro, Tsutsui Hiroko & Nakanishi Kenji -- Regulatory T cells / Christopher Corrigan & Kimuli Ryanna -- A role for invariant NKT cell subsets in the pathogenesis of various allergic disorders / Masaru Taniguchi [and others] -- Regulatory roles of B cells in the allergy and inflammation / Kiyoshi Takatsu, Masashi Ikutani & Yoshinori Nagai -- Mast cells / Steve Galli & Mindy Tsai -- Eosinophils / James Lee, Nancy Lee, Sergei Ochkur & Mark Dahl -- Basophils / Don McGlashan -- Epithelial cells / Darryl Knight [and others] -- Fibroblasts / Alastair Stewart, Lillian Soon & Michael Schuliga -- Smooth muscle cells / Andrew Halayko -- IL-4/IL-13/IL-9 / Kenji Izuhara [and others] -- IL-3/IL-5/GM-CSF / Manuel Jordana ... [et a.]l -- IL-15, IL-17, and IL-25 / Hiroshi Nakajim & Itsuo Iwamoto -- TSLP / Yong-Jun Liu & Kazuhiko Arima -- Interleukin-10 / Larry Borish, Whitney W. Stevens & John W Steinke -- Anti-TNF strategies in experimental asthma and clinical trials : what have we learned? / Christopher Brightling [and others] -- Profibrotic and angiogenic factors in asthma / Francesca Levi- Schaffer & Neville Berkman -- Chemokines / Luis Manuel Teran Juarez & Juan R. Velazquez -- Epithelial growth factors / Shu Hashimoto & Yaihiro Gont -- Prostanoids / Maria Belvisi, Deborah Clarke & Sarah Maher -- Leukotrienes / Mark Peters Golden & Katsuhide Okunishi -- Proteases in allergy / Hirohisa Saito & Keisuke Oboki -- Toll-like receptors / Chris Karp, Jessica L. Allen & Aurelien Trompette |
| Summary |
This book educates the reader on the molecular and cellular mechanism of allergic diseases in the respiratory tract covering all aspects, from its immunological basis to its application in drug development. In contrast to other books, this book focuses on well-known and newly-emerging cells, cytokins, and mediators involved in the pathogenesis of allergic diseases in the respiratory tract. In particular, this book emphasises the findings of novel drug targets. This book allows immunologists, allergologists and researchers in the pharmaceutical industry to learn and appreciate the target biolog |
| Bibliography |
Includes bibliographical references and index |
| Notes |
English |
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Print version record |
| Subject |
Antiallergic agents.
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Allergy -- Treatment
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Anti-inflammatory agents.
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Drugs -- Design.
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Anti-Allergic Agents
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Hypersensitivity -- drug therapy
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Anti-Inflammatory Agents
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Drug Design
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MEDICAL -- Pharmacology.
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Allergy -- Treatment
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Anti-inflammatory agents
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Antiallergic agents
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Drugs -- Design
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| Form |
Electronic book
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| Author |
Izuhara, Kenji
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Holgate, S. T
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Wills-Karp, Marsha
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| ISBN |
9781444346688 |
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1444346687 |
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9781444346664 |
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1444346660 |
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1444330144 |
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9781444330144 |
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1283204932 |
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9781283204934 |
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9786613204936 |
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6613204935 |
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