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Title Immunologic signatures of rejection / Francesco M. Marincola, Ena Wang, editors
Published New York : Springer, 2011


Description 1 online resource (vii, 353 pages) : color illustrations
Contents pt. 1. Preamble -- pt. 2. The immune biology of rejection : basic principles -- pt. 3. Circulating patterns associated with chronic and acute immune pathology -- pt. 4. Tissue-specific patterns associated with chronic inflammatory processes -- pt. 5. Signatures associated with acute rejection
Summary This book collects salient observational data, derived predominantly from human studies, regarding the mechanism(s) of rejection in various pathologic conditions; the premise is that immune rejection, better defined as "immune-mediated, tissue-specific destruction" (TSD), comprises a broad range of phenomena ranging from tumor regression, to clearance of pathogen through destruction of infected cells, autoimmunity, allograft rejection by the host and host versus graft reactions. Like different hands can turn on or off a switch, distinct mechanisms can trigger TSD; however, a convergent pathway is ultimately observed when TSD occurs consisting of a dramatic switch from chronic to acute inflammation leading to the activation of a restricted number of genes that we comprise in the immunologic constant of rejection (ICR) model. Although the ICR model does not address "why" rejection occurs but rather "how", and it may not contribute an explanation for the determinism of rejection, it provides, if correct, a simplified road map about the convergent pathways leading to TSD. This offers the opportunity to identify a common target for immune manipulation with therapeutic purposes since ICR-related pathways are restricted in expression to the tissues in which TSD occurs while are shut off in the rest of a normal organism. The book includes chapters from outstanding basic and/or observational scientists that have contributed to this area either by defining mechanisms relevant to the understanding of the inflammatory switch or by describing how this occurs in human tissues under different pathological conditions. We would like to entice our reader(s) to test with us, through, the readings, whether our hypothesis is correct; we predict that common themes will emerge particularly if attention will be paid to the general phenomenon of TSD rather than the peculiarities of individual pathologies. With the hope of having contributed with this book something novel and important and we wish our reader a pleasant journey in the wondrous land of immune-mediated, tissue-specific destruction
Analysis biomedische wetenschappen
Medicine (General)
Geneeskunde (algemeen)
Bibliography Includes bibliographical references and index
Notes Print version record
Subject Immunology.
Immunosuppressive agents.
Autoimmune Diseases -- immunology
Allergy and Immunology
Immunosuppressive Agents
Graft Rejection -- immunology
Hypersensitivity, Delayed -- immunology
Models, Immunological
Neoplasm Regression, Spontaneous -- immunology
Immunosuppressive agents
Form Electronic book
Author Marincola, Francesco M.
Wang, Ena.
ISBN 9781441972194