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Title Molecular aspects of innate and adaptive immunity / edited by Kenneth B.M. Reid and Robert B. Sim
Published Cambridge, UK : Royal Society of Chemistry, ©2008


Description 1 online resource (xiii, 297 pages) : illustrations (some color)
Contents Section 1. Antibodies. Chapter 1. R.R. Porter and the structure of antibodies / Lisa A. Steiner and Julian B. Fleischman -- Chapter 2. Chemical engineering of therapeutic antibodies / George T. Stevenson and Weng Leong -- Section 2. The complement system. Chapter 3. The evolution of complement systems / Alister W. Dodds -- Chapter 4. Structure and function of the C1 complex : a historical perspective / Gérard J. Arlaud -- Chapter 5. Complement components C3 and C4 / S.K. Alex Law -- Chapter 6. Complement control proteins and receptors from FH to CR4 / Robert B. Sim [and others] -- Chapter 7. Biology and genetics of complement C4 / Michael C. Carroll -- Section 3. Collections and ficolins in innate immunity. Chapter 8. The structure of Mannan-binding lectin and its functional relevance / Jinhua Lu and Steffen Thiel -- Chapter 9. Personal accounts of the discovery of MASP-2 and its role in the MBL pathway of complement activation / Thomas Vorup-Jensen and Jens Chr. Jensenius -- Chapter 10. The structure and function of ficolins, MBLs and MASPs / Russell Wallis, Anders Krarup and Umakhanth Venkatraman Girija -- Chapter 11. Surfactant protein D and glycoprotein 340 / Jens Madsen and Uffe Holmskov -- Section 4. Cell surface proteins : immunoglobulin superfamily and integrins. Chapter 12. Leukocyte surface proteins : purification and characterization / A. Neil Barclay -- Chapter 13. Cell surface integrins / Suet-Mien Tan and S.K. Alex Law -- Section 5. Immunogenetics and major histocompatibility complex class III analysis. Chapter 14. Molecular genetics of the major histocompatibility complex class III region / R. Duncan Campbell, Wendy Thomson and Bernard Morley -- Chapter 15. Functional characterization of major histocompatibility complex class III region genes / R. Duncan Campbell, Caroline M. Milner and Begona Aguado -- Section 6. Hyaluronan-binding proteins in inflammation. Chapter 16. Hyaluronan-bind proteins in inflammation / Anthony J. Day [and others] -- Subject index
Summary This book brings together central themes covering proteins of the immune system with special emphasis on the protein chemistry of the system. The understanding, at the molecular level, of the interactions between innate and adaptive arms of the immune system is currently a hot topic, particularly to those interested in immunology - especially susceptibility to infectious diseases. This book provides a survey of topics, in the area of innate and adaptive immunity, which have been researched within the MRC Immunochemistry Unit, at Oxford University, over a period of forty years. The topics include: " antibody structure - for which the first Director of the Immunochemistry Unit, Professor RR Porter, was awarded a Nobel prize in 1972 " the characterization of membrane proteins on lymphoid cells - leading to the concept of these molecules belonging to an immunoglobulin super family " the proteins of the human serum complement system - one of the body's major defences against microbial infection " the human cell -surface integrins and the hyaluronan- binding proteins, which are involved in regulation of inflammation at cell surfaces and within the extracellular matrix " the family of collectin molecules - containing distinct globular carbohydrate -binding domains linked to collagen-like regions - which play important roles in innate immunity in the lungs and bloodstream by immediate recognition and clearance of microbial pathogens Each chapter in the book gives a brief historical background to a topic and then provides a survey of recent advances in the field and are written by internationally recognised renowned experts. The theme running through the chapters is that of protein structure-function relationships - including, amongst others, descriptions of quaternary structures of large oligomeric proteins, of Factor H and C1q binding to specific ligands, and of the chemistry of the mechanism of catalysis of covalent binding of activated C3 and C4 proteins to nucleophilic groups on microbial surfaces. In several chapters excellent descriptions are given with respect to how the immune system can be recruited to combat microbial infection - via proteins of both the innate and adaptive immune systems. The book also includes notable chapters which are excellent examples of the importance of how the isolation, characterisation, protein engineering and crystallisation has resulted in a full understanding of complex protein-protein interactions involved in the recognition and triggering events of important sections of the immune system: -Structure and Function of the C1 Complex - Gerard J. Arlaud -Chemical Engineering of Therapeutic Antibodies - George T Stevenson -Leukocyte surface proteins - purification and characterisation - A. Neil Barclay -Cell Surface Integrins - Suet-Mien Tan and S.K. Alex Law This book is aimed primarily at established senior research scientists, postdoctoral research scientists and PhD students who have an interest in proteins of the immune system. However, the wide range of immunity system topics, while staying broadly within innate/adaptive immunity will also appeal to a wider audience
Bibliography Includes bibliographical references and index
Notes Online resource; title from title screen (viewed on Apr 24, 2009)
Subject Natural immunity.
Molecular immunology.
Immune System Phenomena -- genetics
Immunity, Innate
Biochemical immunology.
Molecular biology.
MEDICAL -- Immunology.
Molecular immunology
Natural immunity
Form Electronic book
Author Reid, Kenneth B. M., 1943-
Sim, Robert B
LC no. 2009417275
ISBN 9781847558848