I. Basic research. Indirect antimicrobial effects. Effects of antibiotics on Pseudomonas aeruginosa virulence factors and quorum-sensing system / Kazuhiro Tateda, Theodore J. Standiford and Keizo Yamaguchi -- Anti-inflammatory effects. Antibiotics, inflammation and its resolution : an overview / Michael J. Parnham ; The cytoprotective interactions of antibiotics with human ciliated airway epithelium / Charles Feldman and Ronald Anderson ; Chemotaxis / Jun-ichi Kadota ; Cytokines / Hajime Takizawa ; Antibacterial agents and the oxidative burst / Marie-Thérèse Labro ; Immune system / Jun-ichi Kadota -- Mucoregulatory effects. Macrolides and mucus production / Kiyoshi Takeyama ; Ion channel regulation / Jun Tamaoki -- II. Clinical results. The use of macrolides for treatment of diffuse panbronchiolitis / Arata Azuma and Shoji Kudoh ; Macrolides in cystic fibrosis / Adam Jaffé and Andrew Bush ; Macrolides and upper airway/sinus disease / Kazuhiko Takeuchi, Yuichi Majima and Qutayba Hamid ; Benefits of macrolides in the treatment of asthma / Rose Jung, Mark H. Gotfried and Larry H. Danziger ; Roles of antibiotics in treatment of lung injury / Arata Azuma ; Antibiotics and cancer, arthritis and IBD / Keiichi Mikasa, Kei Kasahara and Eiji Kita ; Anti-inflammatory properties of antibiotics other than macrolides / Bruce K. Rubin, Markus O. Henke and Axel Dalhoff
Summary
Although the potential for immunomodulation has been recognized for many years there has been an explosion of data in this field with relevance especially to the treatment of chronic airway diseases. This work provides background information for the clinician as well as in depth exploration of cutting edge science