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Title Immunotoxicity, immune dysfunction, and chronic disease / Rodney R. Dietert, Robert W. Luebke, editors
Published New York : Humana Press, ©2012


Description 1 online resource (xv, 451 pages) : illustrations (some color)
Series Molecular and integrative toxicology
Molecular and integrative toxicology.
Contents Part 1. INTRODUCTION -- Introduction to Immunotoxicity / Keith D. Salazar and Rosana Schafer -- The Environment-Immune Route to Chronic Disease / Rodney R. Dietert and Robert W. Luebke -- Part 2. ALLERGIC DISEASES -- Asthma and Respiratory Allergic Disease / David M. Lehmann and Marc A. Williams -- Cutaneous Allergies / David A. Basketter and John P. McFadden -- Food Allergies / Christal C. Bowman -- Part 3. AUTOIMMUNE AND INFLAMMATORY DISEASES AND CONDITIONS -- Factors Involved in Onset of Type 1 Diabetes / Anne Cooke and Paola Zaccone -- Rheumatoid Arthritis / Jean C. Pfau -- Environment, Immune Dysfunction, and Systemic Lupus Erythematosus / Moran Landau Rabbi, Ilan Ben-Zvi, Nancy Agmon-Levin and Yehuda Shoenfeld -- Multiple Sclerosis, Alzheimer's Disease, and Inflammation: A Hypothetical View / Margaret S. Bynoe and Christophe Viret -- Immune Dysfunction in Autism Spectrum Disorders / Milo Careaga, Judy Van de Water and Paul Ashwood -- Atherosclerosis and Inflammatory Heart Disease / DeLisa Fairweather -- Inflammatory Bowel Disease and Celiac Disease: Environmental Risks Factors and Consequences / Rodney R. Dietert -- COPD and Other Inflammatory Diseases of the Lung: Focus on AhR Signaling / Celine A. Beamer, Benjamin P. Seaver and David M. Shepherd -- Environment, the Immune System, and Depression: An Integrative Review and Discussion of the Infection-Defense Hypothesis / Midori Tanaka, Sherry Anders and Dennis K. Kinney -- Part 4. INFECTIONS AND CANCER -- Environmental Toxicants and Susceptibility to Infection / Carsten Heilmann -- Childhood Acute Leukemia / Joseph Wiemels -- Part 5. PREVENTION OF CHRONIC DISEASES -- Reducing the Prevalence of Immune-Based Chronic Disease / Rodney R. Dietert, Jamie C. DeWitt and Robert W. Luebke
Summary Immunotoxicity, Immune Dysfunction, and Chronic Disease is among the first books to illustrate the linkage between environmental risk factors (e.g., chemicals, drugs, diet, lifestyles), environmentally-induced immune dysfunction and the full range of resulting chronic diseases and conditions. There is a detailed discussion of specific immune-based chronic diseases and conditions that emerge in children and adults and affect different physiological systems. The book integrates a consideration of risk factors and specific immunotoxic alterations with disease outcomes. A significant number of diseases and conditions are discussed, such as systemic allergic diseases affecting the lung, skin and gastrointestinal tract, systemic autoimmune diseases (type 1 diabetes, multiple sclerosis and lupus) and chronic conditions that are not traditionally associated with chemically-mediated immunomodulation (depression, frailty, and atherosclerosis). Inflammatory dysregulation is a common thread that connects many of the diseases and conditions discussed in this book and provides a central focus.¡ Individual chapters are organized by disease with the addition of chapters that provide integrative information on: 1) patterns of disease comorbidities and 2) the safety testing of chemicals and drugs to reduce the risk of immune dysfunction.¡ Each chapter contains a summary of key points as well as recommendations when appropriate. The book stresses the benefits of identifying the environmental risk factors of immune-mediated chronic disease and the potential to reduce the prevalence of these diseases and conditions.¡ This¡volume is a valuable resource for researchers, clinicians, risk assessors and regulators and students.¡ ¡
Analysis Medicine
Molecular Medicine
Bibliography Includes bibliographical references and index
Notes English
Print version record
Subject Chronic diseases -- Immunological aspects
Chronic diseases.
Immunologic diseases.
Chronic Disease
Immune System Diseases
Immunotoxins -- adverse effects
MEDICAL -- Long-Term Care.
Immunologic diseases
Chronic diseases
Form Electronic book
Author Dietert, Rodney R.
Luebke, Robert W.
ISBN 9781617798122