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Title Immunotoxicity testing : methods and protocols / edited by Jamie C. DeWitt, Cheryl E. Rockwell, Christal C. Bowman
Edition Second edition
Published New York, N.Y. : Humana Press : Springer, ©2018


Description 1 online resource (xiii, 412 pages) : illustrations (some color)
Series Methods in molecular biology, 1940-6029 ; 1803
Methods in molecular biology (Clifton, N.J.) ; v. 1803. 1064-3745
Contents Immunotoxicology : a brief history / Kenneth L. Hastings -- Clinical immunotoxicology / L. Peyton Myers -- Investigative immunotoxicology / Stacey E. Anderson and Hillary L. Shane -- Developmental immunotoxicity (DIT) testing : current recommendations and the future of DIT testing / Annalise N. vonderEmbse and Jamie C. DeWitt -- Markers of inflammation / Dori R. Germolec, Kelly A. Shipkowski, Rachel P. Frawley, and Ellen Evans -- Sheep erythrocyte T-dependent antibody response (TDAR) / Gregory S. Ladics -- Methylated bovine serum albumin (mBSA)-induced delayed-type hypersensitivity in mice / Jessica Margaret Sido -- Use of the LLNA:BrdU-ELISA for skin sensitization hazard assessment / David M. Lehmann -- Host resistance assays / Stefanie C.M. Burleson, Wendy Jo Freebern, Florence G. Burleson, Gary R. Burleson, Victor J. Johnson, and Robert W. Luebke -- Enhanced histopathology evaluation of lymphoid organs / Susan A. Elmore -- Tumor challenges in immunotoxicity testing / Sheung P. Ng and Judith T. Zelikoff -- Flow cytometry for the immunotoxicologist / Scott T. Espenschied, Robert M. Tighe, and Kymberly M. Gowdy -- Evaluation of cell-mediated immune function using the cytotoxic T-lymphocyte assay / Gary R. Burleson, Florence G. Burleson, and Rodney R. Dietert -- Evaluation of cell proliferation and apoptosis in immunotoxicity testing / Mitzi Nagarkatti, Sadiye Amcaoglu Rieder, and Prakash S. Nagarkatti -- Natural killer (NK) cell assays in immunotoxicity testing / Qing Li -- Dendritic cell assays / Joanna M. Kreitinger and David M. Shepherd -- Evaluating macrophages in immunotoxicity testing / Jennifer Franko, Jamie L. McCall, and John B. Barnett -- Evaluating cytokines in immunotoxicity testing / Emanuela Corsini and Robert V. House -- Functional Assays of Hematopoietic Stem Cells in Toxicology Research / Michael D. Laiosa -- CD4+ T cell differentiation and activation / Jim Reed and Scott A. Wetzel -- Isolation and identification of innate lymphoid cells (ILCs) for immunotoxicity testing / Elia D. Tait Wojno and Celine A. Beamer -- Evaluating antigen-specific IgE using the rat basophil leukemia cell (RBL) assay / Marsha D.W. Ward and Lisa B. Copeland -- Challenges for integrating immunotoxicology into the twenty-first-century toxicology testing paradigm / Peer W.F. Karmaus and Agnes L. Karmaus
Summary Annotation This fully updated volume utilizes the expertise of scientists currently engaged in immunotoxicity testing to provide the reader with lab-ready procedures and the background information needed to identify effective testing approaches. Dedicated to identifying and describing exogenous agents that can modify immune function, uncovering modes and mechanisms of action for such agents, and translating data from the laboratory and from the clinic to better predict health risks as well as benefits to those who are exposed to immunomodulatory agents, immunotoxicity testing continues to be a vital field of study, and this collection highlights both the "tried and true" methods as well as alternative protocols that have been more recently developed. Written in the highly successful Methods in Molecular Biology format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and practical, Immunotoxicity Testing: Methods and Protocols, Second Edition serves as a valuable contribution to the continued evolution and the application of immunotoxicity testing
Bibliography Includes bibliographical references and index
Notes Online resource; title from PDF title page (SpringerProtocol viewed June 8, 2018)
Subject Immunotoxicology.
Immune system -- Effect of drugs on
Drugs -- Toxicology.
Diseases -- Animal models.
Immunotoxins -- adverse effects
Disease Models, Animal
Drug Evaluation -- methods
Drug-Related Side Effects and Adverse Reactions -- immunology
Immunologic Tests -- methods
Toxicity Tests -- methods
Medical -- Pharmacology.
Diseases -- Animal models
Drugs -- Toxicology
Immune system -- Effect of drugs on
Genre/Form Laboratory manuals
Laboratory manuals.
Manuels de laboratoire.
Form Electronic book
Author DeWitt, Jamie C., editor
Rockwell, Cheryl E., editor
Bowman, Christal C., editor
ISBN 9781493985494