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Title Molecular immunotoxicology / edited by Emanuela Corsini and Henk van Loveren
Published Weinheim : Wiley-VCH, 2014


Description 1 online resource
Contents Molecular Immunotoxicology; Contents; Preface; List of Contributors; Chapter 1 The Evolution of Immunotoxicology; 1.1 Introduction; 1.2 Immune-Mediated Environmental Lung Diseases; 1.3 Immunotoxic Drug Reactions; 1.4 Autoimmunity; 1.5 Immunosuppression; 1.6 Allergic Contact Dermatitis (ACD); 1.7 Summary; References; Chapter 2 Overview on the Mechanisms Underlying Chemical-Induced Immunotoxicity; 2.1 Introduction; 2.2 Mechanisms of Immunotoxicity; 2.2.1 Interference with Cellular Signaling; Receptor-Mediated Immunotoxicity; Non-receptor-Mediated Immunotoxicity
2.2.2 Adducts Formation and Role of ROS2.3 Conclusions; References; Chapter 3 Use of Toxicogenomics in Immunotoxicology; 3.1 Introduction; 3.2 Toxicogenomics; 3.2.1 Profiling Gene Expression; 3.2.2 Pathway Arrays; 3.2.3 Comparative Evaluation of Immunotoxicants; 3.2.4 miRNA and siRNA, Gene Expression Regulators; 3.2.5 mRNA Splicing; 3.2.6 RNA-Seq; 3.2.7 Proteomics; 3.2.8 Molecular Genomics; 3.2.9 Phenotypic Anchoring, Dose Response, Time Course; 3.3 Bioinformatics and Data Analysis; 3.3.1 Effect Markers and Machine Learning
3.4 Multiple Omic Approaches in the Evaluation of Immunosuppressive Compounds3.4.1 Multiple Omic Approaches in the Study of Hypersensitivity; 3.5 Summary and Conclusions; References; Chapter 4 Breakdown of the Molecular Processes Driving the Adverse Outcome Pathways (AOPs) of Skin and Respiratory Sensitization Induction in Humans Exposed to Xenobiotics and Proteins; 4.1 Introduction; 4.2 The AOP for Skin Sensitization; 4.3 The Molecular Processes in the MOA for Sensitization Induction; 4.3.1 Bioavailability: the Compound Acquires Access to the System
4.3.4 Dendritic Cell Activation: from Innate Responses to DC Maturation4.3.5 Dendritic Cell Migration: Translating the Message into Specific Actions; 4.3.6 T-Cell Priming and Proliferation: the Turning-Point between Sensitization and Effect; 4.4 Summary; References; Chapter 5 Chemical Allergen-Induced Skin Cell Activation; 5.1 Introduction; 5.2 Breaching the Barriers; 5.3 Role of the Extracellular Matrix in Skin Inflammation; 5.4 Cytoprotective Responses and Skin Inflammation; 5.5 Skin Dendritic Cells -- Tolerance versus Immunity; 5.6 DC Activation and Migration; 5.7 The Role of Danger Signals
Summary The first comprehensive reference on immunotoxicology using analyses based on molecular effects rather than on animal models. Following an introduction to immune system pathways and toxicity mechanisms from a systemic perspective, the main part of the book surveys individual molecular mechanisms of important immunotoxicants, from PAHs to biopharmaceuticals, and from receptor-mediated toxicity to nanoparticle toxicity. Taken together, the knowledge presented here provides an up-to-date overview of this hot topic that can be directly applied to the prediction and characterization of immunotoxic e
Bibliography Includes bibliographical references and index
Notes Print version record
Subject Immunotoxicology.
Immunotoxins -- adverse effects
Immune System Diseases -- chemically induced
HEALTH & FITNESS -- Diseases -- General.
MEDICAL -- Clinical Medicine.
MEDICAL -- Diseases.
MEDICAL -- Evidence-Based Medicine.
MEDICAL -- Internal Medicine.
Form Electronic book
Author Corsini, Emanuela
Loveren, Henk van
ISBN 9783527676972