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Title Immunotoxicity testing : methods and protocols / edited by Rodney R. Dietert
Published New York, N.Y. : Humana Press, ©2010


Description 1 online resource (x, 430 pages) : illustrations
Series Springer Protocols
Methods in molecular biology, 1940-6029 ; 598
Springer protocols (Series)
Methods in molecular biology (Clifton, N.J.) ; v. 598.
Contents Immunotoxicology testing: past and future / Michael I. Luster, G. Frank Gerberick -- Developmental immunotoxicity (DIT): the why, when, and how of DIT testing / Rodney R. Dietert, Jamie DeWitt -- An In vivo tiered approach to test immunosensitization by low molecular weight compounds / Irene S. Ludwig, Lydia M. Kwast, Daniëlle Fiechter, Raymond H. Pieters -- Risk of autoimmune disease: challenges for immunotoxicity testing / Rodney R. Dietert, Janice M. Dietert, Jerrie Gavalchin -- Markers of inflammation / Dori R. Germolec, Rachel P. Frawley, Ellen Evans -- Evaluating macrophages in immunotoxicity testing / John B. Barnett, Kathleen M. Brundage -- Host resistance assays including bacterial challenge models / Florence G. Burleson, Gary R. Burleson -- Viral host resistance studies / Wendy Jo Freebern -- Parasite challenge as host resistance models for immunotoxicity testing / Robert W. Luebke -- Tumor challenges in immunotoxicity testing / Sheung Ng, Kotaro Yoshida, Judith T. Zelikoff -- The T-dependent antibody response to keyhole limpet hemocyanin in Rodents / Lisa M. Plitnick, Danuta J. Herzyk -- The Sheep erythrocyte T-dependent antibody response (TDAR) / Kimber L. White, Deborah L. Musgrove, Ronnetta D. Brown -- The Delayed type hypersensitivity assay using protein and xenogeneic cell antigens / Rodney R. Dietert, Terry L. Bunn, Ji-Eun Lee -- The Cytotoxic T lymphocyte assay for evaluating cell-mediated immune function / Gary R. Burleson, Florence G. Burleson, Rodney R. Dietert -- NK cell assays in immunotoxicity testing / Qing Li
The Local lymph node assay and skin sensitization testing / Ian Kimber, Rebecca J. Dearman -- Use of contact hypersensitivity in immunotoxicity testing / Jacques Descotes -- Evaluation of apoptosis in immunotoxicity testing / Mitzi Nagarkatti, Sadiye Amcaoglu Rieder, Dilip Vakharia, Prakash S. Nagarkatti -- Dendritic cells in immunotoxicity testing / Donghong Gao, David A. Lawrence -- Evaluating cytokines in immunotoxicity testing / Emanuela Corsini, Robert V. House -- Flow cytometry in preclinical drug development / Patrick B. Lappin -- Enhanced histopathology evaluation of lymphoid organs / Susan A. Elmore -- Immunotoxicity testing in nonhuman primates / Stephanie Grote-Wessels, Werner Frings, Clifford A. Smith, Gerhard F. Weinbauer -- Fundamentals of clinical immunotoxicology / Robert V. House -- In vivo functional tests for assessing immunotoxicity in birds / Keith A. Grasman -- In vitro testing for direct immunotoxicity: state of the art / D.P. Lankveld, H. Loveren, K.A. Baken, R.J. Vandebriel
Summary Recent critical advances in the field of immunotoxicology have led to incredible contributions to basic science, including crucial improvements in human risk assessment. In Immunotoxicity Testing: Methods and Protocols, expert researchers explore these changes, providing the reader with current, lab-ready procedures, along with the corresponding background information that is necessary to identify effective testing approaches for chemicals and drugs. Among the first volumes to meld consideration of immunotoxicity testing strategies with a comprehensive presentation of detailed laboratory protocols, chapters include a description of the evolution of immunotoxicity testing, a look at the importance of immunotoxicity testing for health risk reduction, and ideas concerning the future of the field. Composed in the highly successful Methods in Molecular Biology(tm) series format, most chapters contain a brief introduction, step-by-step methods, a list of necessary materials, and a Notes section which shares tips from the experts on troubleshooting and avoiding known pitfalls. Comprehensive and innovative, Immunotoxicity Testing: Methods and Protocols is a critical, one-stop reference resource for the most important and commonly used laboratory protocols in immunotoxicology
Analysis toxiciteit
autoimmune diseases
disease resistance
Notes Title from PDF title page (viewed December 9, 2009)
Bibliography Includes bibliographical references and index
Notes English
Subject Immunotoxicology.
Immune system -- Effect of drugs on
Drugs -- Toxicology.
Diseases -- Animal models.
Immunotoxins -- adverse effects
Disease Models, Animal
Drug Evaluation -- methods
Drug-Related Side Effects and Adverse Reactions -- immunology
Immunologic Tests -- methods
Toxicity Tests -- methods
Diseases -- Animal models
Drugs -- Toxicology
Immune system -- Effect of drugs on
Genre/Form Laboratory manuals
Laboratory manuals.
Manuels de laboratoire.
Form Electronic book
Author Dietert, Rodney R
ISBN 9781607614012