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Author Heine, Vivi M.

Title Induced pluripotent stem cells in brain diseases : understanding the methods, epigenetic basis, and applications for regenerative medicine. / Vivi M. Heine ... [and others]
Published Dordrecht : Springer, 2011


Location Call no. Vol. Availability
 W'PONDS  612.64018 Hei/Ips  AVAILABLE
Description xv, 59 pages : illustrations ; 24 cm
Series SpringerBriefs in neuroscience
SpringerBriefs in neuroscience.
Contents Contents note continued: 3.Prospects for Cell Replacement Therapies for Neurodegenerative Diseases -- 3.1.Cell Therapies for Neurodegenerative Diseases -- 3.2.Parkinson's Disease -- 3.2.1.Etiology and Pathogenesis -- 3.2.2.Treatment Options for Parkinson's Disease -- 3.2.3.Fetal Tissue Transplantation -- 3.2.4.Cell Therapy -- 3.3.Childhood Brain White Matter Disorders -- 3.3.1.Etiology and Pathogenesis -- 3.3.2.Prospect for Cell Therapy -- 3.4.Conclusion -- References -- 4.Conclusions -- 4.1.The Promise and Limitations of iPSCs -- 4.2.Concluding Remarks
Machine generated contents note: 1.Reprogramming: A New Era in Regenerative Medicine -- 1.1.Stem Cells -- 1.2.Reprogramming -- 1.2.1.Viral Vectors -- 1.2.2.Non-Viral Methods -- 1.3.Pluripotency, Efficiency, and Identity -- 1.3.1.Measuring Pluripotency -- 1.3.2.Reprogramming Efficiency -- 1.3.3.iPSCs Versus ESCs -- 1.3.4.State of Pluripotency -- 1.4.Differentiation -- 1.4.1.Motor Neurons -- 1.4.2.Dopaminergic Neurons -- 1.4.3.Oligodendrocytes -- 1.4.4.Astrocytes -- 1.4.5.Selection of Differentiated Cells -- 1.5.Trans-Differentiation -- References -- 2.Understanding Epigenetic Memory is the Key to Successful Reprogramming -- 2.1.Epigenetic Influences on Gene Expression -- 2.1.1.DNA Methylation -- 2.1.2.Histone Modification -- 2.1.3.Noncoding RNA -- 2.1.4.Common Epigenetic Traits -- 2.2.Epigenetic Control in De-, Re-, and Trans-Differentiation -- 2.3.Using Epigenetics to Aid Reprogramming -- 2.4.Epigenetics Affecting Neural Cell Fate -- 2.5.A Caveat -- References --
Summary The principle goal of regenerative medicine is the restoration of damaged, dysfunctional, or missing cellular tissue, up to and including whole organs. Growing healthy replacement tissue, in vivo or in vitro, plays an important role in anticipated therapies. To generate competent replacement material, scientists confront the fundamental issues of cellular identity and plasticity. The basis of this book is formed by the theses of three talented master students: Stephanie Dooves, Dwayne Holmes and Judith Wagner. Their work discusses the recent advancements in the field of cell reprogramming. Although it is clear that we can produce pluripotent stem cells from differentiated cells, there are still a lot of unsolved issues. These issues include the efficiency and safety of reprogramming, the similarity of induced pluripotent (iPSCs) to embryonic stem cells (ESCs) and the epigenetic status of the cells. In the third chapter, the use of stem cell therapy for brain diseases will be discussed, with a focus on Parkinson's disease (PD) and Vanishing White Matter (VWM)
Analysis Life sciences
Notes Formerly CIP. Uk
Bibliography Includes bibliographical references
Subject Brain -- Diseases -- Treatment.
Cellular therapy.
Gene expression.
Neural stem cells.
Nervous system -- Degeneration -- Treatment.
Regenerative medicine.
Somatic cells.
Stem cells.
Induced Pluripotent Stem Cells.
Epigenomics -- methods.
Neurodegenerative Diseases -- therapy.
Regenerative Medicine.
Author Heine, Vivi M.
LC no. 2011941719
ISBN 9789400728158 (paperback)