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Title DNA topoisomerases and cancer / Yves Pommier, editor
Published New York, NY : Springer, ©2012


Description 1 online resource (xi, 443 pages)
Series Cancer drug discovery and development
Cancer drug discovery and development.
Contents Introduction and historical perspective / Patrick Forterre -- Human DNA topoisomerase I : structure, enzymology and biology / James J. Champoux -- Mitochondrial topoisomerases / Ilaria Dalla Rosa, Yves Pommier, and Hongliang Zhang -- Structure and mechanism of eukaryotic type IIA topoisomerases / James M. Berger and Neil Osheroff -- Essential functions of topoisomerase III-alpha in the nucleus and mitochondria / Stefanie Hartman Chen, Jianhong Wu, and Tao-shih Hsieh -- DNA topoisomerase I and illegitimate recombination / Céline Auzanneau and Philippe Pourquier -- Topoisomerase-induced DNA damage / Yves Pommier and Neil Osheroff -- Topoisomerases and carcinogenesis : topoisomerases III-alpha and BLM / Mounira Amor-Guéret and Jean-François Riou -- Topoisomerases inhibitors : a paradigm for interfacial inhibition / Christophe Marchand and Yves Pommier -- Topoisomerases I inhibitors : chemical biology / Beverly A. Teicher -- Topoisomerases II inhibitors : chemical biology / Anna Rogojina [and others] -- Topoisomerases I inhibitors : current use and prospects / Yan Makeyev [and others] -- Topoisomerases II inhibitors : current use and prospects / Olivier Mir [and others] -- Transcriptional stress by camptothecin : mechanisms and implications for the drug antitumor activity / Giovanni Capranico [and others] -- Mechanisms regulating cellular responses to DNA topoisomerases I-targeted agents / Piero Benedetti and Mary-Ann Bjornsti -- Tyrosyl-DNA-phosphodiesterase / Thomas S. Dexheimer [and others] -- Ubiquitin and ubiquitin-like proteins in repair of topoisomerases-mediated DNA damage / Shyamal D. Desai -- Repair of topoisomerases II-mediated DNA damage : fixing DNA damage arising from a protein covalently trapped on DNA / John L. Nitiss [and others] -- Topoisomerases and apoptosis / Olivier Sordet and Stéphanie Solier
Summary Annotation DNA topoisomerases represent an essential family of DNA processing enzymes and a large number of topoisomerase inhibitors are used clinically for the treatment of various human cancers. Novels drugs are in clinical development both against type I and type II topoisomerases. The book will include basic biochemical and structural reviews for the cancer-relevant topoisomerases. It will describe how topoisomerase dysfunctions can damage the genome and increase the risk of cancers, and the involvement of topoisomerases in programmed cell death. The book will also present the various topoisomerase inhibitors in clinical use and development and their molecular and cellular mechanisms of action
Analysis Medicine
Cancer Research
Bibliography Includes bibliographical references and index
Notes English
Subject DNA topoisomerases -- Inhibitors
Cancer -- Chemotherapy.
Neoplasms -- drug therapy
Antineoplastic Agents -- therapeutic use
DNA Topoisomerases, Type I -- chemistry
DNA Topoisomerases, Type I -- genetics
Topoisomerase I Inhibitors
SCIENCE -- Life Sciences -- Biochemistry.
Cancer -- Chemotherapy.
Form Electronic book
Author Pommier, Yves.
ISBN 9781461403234