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Title New strategies in stroke intervention : ionic transporters, pumps, and new channels / edited by Lucio Annunziato
Published Totowa, N.J. : Humana ; Totowa, N.J. : Humana, ©2009

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Description 1 online resource
Series Contemporary neuroscience
Contemporary neuroscience.
Contents Basis of Ionic Dysregulation in Cerebral Ischemia -- Why have Ionotropic and Metabotropic Glutamate Antagonists Failed in Stroke Therapy? -- Mitochondrial Channels as Potential Targets for Pharmacological Strategies in Brain Ischemia -- Endoplasmic Reticulum Calcium Homeostasis and Neuronal Pathophysiology of Stroke -- The Na + /Ca 2+ Exchanger: A Target for Therapeutic Intervention in Cerebral Ischemia -- The "Loop" Diuretic Drug Bumetanide-Sensitive Na + -K + -Cl -- Cotransporter in Cerebral Ischemia -- The Na + /H + Exchanger: A Target for Therapeutic Intervention in Cerebral Ischemia -- The Na + /K + -ATPase as a Drug Target for Ischemic Stroke -- Acid-Sensing Ion Channels (ASICs): New Targets in Stroke Treatment -- Role of TRPM7 in Ischemic CNS Injury -- Subtypes of Voltage-Gated Ca 2+ Channels and Ischemic Brain Injury -- The Diverse Roles of K + Channels in Brain Ischemia -- Clinical Trials with Drugs Targeting Ionic Channels, Antiporters, and Pumps in Ischemic Stroke
Summary Ischemic brain damage represents a major source of morbidity and mortality in westernized society and poses a significant financial burden on the health care system. To date, few effective therapies have been realized to treat stroke and promising avenues have not proven clinically useful. Recent evidence, however, suggests that channels, pumps, and ionic exchangers are involved in CNS ischemia and ischemic stroke, but the potential contribution of these channels for curing stroke is far less understood than for many other normal and pathological conditions. New Strategies in Stroke Intervention: Ionic Channels, Pumps, and Transporters analyzes the roles played by targets in stroke development and the potential action of drugs modulating these proteins. This book provides a groundbreaking review of these ionic channels, pumps, and transporters as regulators of neuronal ionic homeostasis, providing a better understanding of ischemic brain disorders and the new pharmacological avenues for a cure. It will be a useful tool for researchers working in this field, and any student interested in the physiological, pathophysiological, and pharmacological features of stroke damage. About the Editor: Lucio Annunziato is a professor of pharmacology in the School of Medicine at the University of Naples ''Federico II'', Italy. He is coordinator of the University's neuroscience Ph. D. program and director of the Department of Neuroscience. He is also the president elect of the Italian Society of Neuroscience. Dr. Annunziato has authored more than 150 full papers and his scientific interest is mainly devoted to the molecular pharmacology of plasma membrane transporters and ionic channels involved in the pathophysiology of stroke. Most of his recent papers have appeared in the most qualified international journals in the field of ischemic neurodegeneration
Analysis farmacologie
pharmacology
toxicologie
toxicology
neurologie
neurology
anesthesie
anaesthesia
geneeskunde
medicine
biomedische wetenschappen
biomedicine
neurowetenschap
neuroscience
cardiologie
cardiology
Medicine (General)
Geneeskunde (algemeen)
Bibliography Includes bibliographical references and index
Notes Print version record
Subject Cerebrovascular disease -- Treatment
Brain -- drug effects
Ion Channels -- therapeutic use
Ion Pumps -- therapeutic use
Stroke -- drug therapy
MEDICAL -- Neurology.
Biomédecine.
Sciences de la vie.
Cerebrovascular disease -- Treatment
Form Electronic book
Author Annunziato, Lucio.
ISBN 9781607612803
1607612801
1607612798
9781607612797