Limit search to available items
Book Cover
E-book

Title Beta cells : functions, pathology, and research / Sarah E. Gallagher, editor
Published New York : Nova Biomedical Books, ©2011

Copies

Description 1 online resource (xi, 176 pages) : illustrations (some color)
Series Cell biology research progress
Cell biology research progress.
Contents BETA CELLS: FUNCTIONS, PATHOLOGY AND RESEARCH ; BETA CELLS: FUNCTIONS, PATHOLOGY AND RESEARCH ; Contents ; Preface ; Stress and Pancreatic Ý Cell Function: Role of Glucocortoids, Exercise and Glucolipotoxicity; Abstract ; Introduction Ý Cell Adaptation Ý Cell Mass in Obesity ; Life Cycle of the Ý Cell ; Glucocorticoids and Ý Cell Function ; Direct Effects of Glucocorticoids on Ý Cells ; Indirect Effects of Glucocorticoids on Ý Cell Function ; Role of GRs on Ý Cell Survival and Replication ; Intermittent Stress and Ý Cell Function ; Exercise Intervention on Ý Cell Function
Exercise Causes Pancreatic Regeneration in Partial Pancreatectomy Models Disposition Index on Ý Cell Function ; Age and Exercise on Ý Cell Function; Glucolipotoxicity on Ý Cell Function ; Glucotoxicity; Lipotoxicity ; Short Term Effects of FFAs ; Long Term Effects of FFAs ; FFAs and ER Stress ; Conclusion ; References ; The Synergistic Effect of Ý Cell Replacement and Immunotherapy on the Treatment of Type 1 Diabetes ; Abstract ; Introduction Ý-Cell Replacement ; Patient-Specific ß-Cells ; 1. Autologous adult stem cell-derived ß-cells ; 2. Induced pluripotent stem cells
3. Transdifferentiation-induced Ý-like cells Embryonic Stem Cell-Derived ß-Cells ; Islet Transplantation; Pancreas Transplantation ; Immunotherapy ; Immunopathology of T1D ; Treg-Based Immunotherapy ; 1. Evidence of Treg function in the control of T1D ; 2. Mechanisms of Treg function in T1D ; 3. Therapeutic potential of Tregs on T1D ; Antigen/ Antibody-Based Immunotherapy ; The Potential Synergistic Role of Ý-Cell Replacement and Immunotherapy ; 1. Bi-Directional Actions of Cell-Based Therapy ; 2. Multiple Functions of Immunotherapy ; 3. Temporal and Spatial Actions of Immunotherapy
VII. Expression of Results and Statistical Analyses 1. Expression of the results ; 2. Statistical analyses ; Results ; I. Effect of Rimonabant Administration (10 Mg/Kg/D) on Body Weight of ZDF Rats; II. Rimonabant Administration (10 Mg/Kg/D) Prevents the Elevation of Blood Glucose Levels of ZDF Rats ; III. Rimonabant Administration (10 Mg/Kg/D) Reduces the Decline of Insulinemia of ZDF Rats ; IV. Rimonabant Administration (10 Mg/Kg/D) Reduces Cell Dysfunction in ZDF Rats; 1. Insulin secretion during static incubation of islets isolated from ZDF rats treated for 2 weeks
Summary And Conclusion Acknowledgments ; References; Antagonizing the Endocannabinoid Pathway Prevents the Development of Diabetes and Ý Cell Dysfunction in Zucker Diabetic Fatty Rats ; Abstract ; Methods ; Results ; Introduction ; Materials and Methods ; I. Drugs and Reagents ; II. Animals ; III. Treatment and Follow-up ; IV. Islet Isolation ; V. Glucose-Stimulated Insulin Secretion (GSIS) Assessment by Static Incubation of Isolated ZDF Rat Islets; VI. Glucose-Stimulated Insulin Secretion (GSIS) Assessment by Perifusion of Isolated ZDF Rat Islets
Bibliography Includes bibliographical references and index
Notes Print version record
Subject Pancreatic beta cells.
Diabetes.
Islets of Langerhans
MEDICAL -- Nutrition.
Diabetes
Pancreatic beta cells
Form Electronic book
Author Gallagher, Sarah E
ISBN 9781617613722
161761372X