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Book Cover
E-book
Author Stephanou, Anastasis

Title JAK-STAT Pathway in Disease
Published Boca Raton : Chapman and Hall/CRC, 2009

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Description 1 online resource (191 pages)
Contents Cover; Title Page; Copyright Page; About the Editor; Contents; Preface; 1. STAT1 and STAT3: Opposing Roles in Cell Death and Cell Cycle Regulation; STAT1 Promotes Apoptosis or Cell Cycle Arrest; STAT1 Interacting Factors; STAT3 a Modulator of Cell Growth and Inhibitor of Apoptosis; STAT3 Interacting Factors; 2. Suppressors of Cytokine Signaling: Functions in Normal Biology and Roles in Disease; Suppressors of Cytokine Signaling; Physiological Roles of the SOCS Proteins; Roles of SOCS Proteins in Disease; 3. JAK/STAT Pathway Signalling in Drosophila melanogaster
Components of the Drosophila JAK/STAT PathwayNegative Pathway Regulators; Developmental Roles; Larval Development; Adult Stages; Future Directions; JAK/STAT Pathway and Chromatin Structure; 4. STATs and Infection; STAT1 and STAT2; STAT3; STAT4 and STAT6; STATS; Drosophila STAT; 5. STAT Protein Regulation of Inflammatory T-Helper Cell Phenotypes; A Brief Overview of the T-Helper Cell Subsets and the In Vivo Consequences of STAT Deletion and Dysf unction; The STAT Protein Network in Effector Th Development
6. Janus Kinase (JAK)-Signal Transducer and Activator of Transcription (STAT) Pathway in Heart DiseaseJAK and STAT Proteins-Molecular Characteristics; JAK-STAT in Cardiomyocyte Hypertrophy; JAK-STAT in Atherosclerosis; JAK-STAT in Hypertension; JAK-STAT in Myocarditis and Dilated Cardiomyopathy; JAK-STAT in Cardioprotection; 7. The Role of the JAK/STAT Pathway in Inflammatory Bowel Diseases; Inflammatory Bowel Diseases; The Role of IL-6/STAT-3 Trans Signaling in IBD; The Role of Other STATs in IBD; 8. STAT1 and STAT3 in Tumorigenesis: Two Sides of the Same Coin?
Differential STAT1 and STAT3 Activation by Cytokines and Growth Factor ReceptorsReciprocal Roles of STAT1 and STAT3 in Tumorigenesis; STAT1 in Tumorigenesis; STAT3 in Tumorigenesis; Alterations in Control Mechanisms of STAT1 and STAT3 Activation; STAT1:STAT3 Cross-Regulation; 9. The Oncogenic Role of STAT Transcription Factors in Breast Cancer; Role of STATs in the Mammary Gland; STATs as Oncogenes; The Oncogenic Role of STAT Transcription Factors in Breast Cancer; The Role of STATs in Mouse Models of Mammary Neoplasia; How Are STATs Constitutively Activated in Mammary Carcinoma?
Relationship of STATs Activity with Invasiveness/MetastasisSTATs as Therapeutic Targets for Cancer Therapy?; 10. Stat5 as Hematopoietic Gatekeeper and Oncogene Upon Tyrosine Kinase-Induced Transformation; Stat5 Functions in Hematopoiesis; Consequences of Stat5 Deletion for Embryo Development and Adult Mice with Focus on Myelo-Eryt hropoiesis; Stat5 in Lymphopoiesis; Stat5 as a Master Regulator of Hematopoietic Cancers?; Stat5 and Transforming Tyrosine Kinases Activated by Chromosomal Rearrangements; Mutated or Amplified Jak Kinases Affecting Stat5 Activity
Notes Mutated Growth Factor Receptors in Jak-Stat Signaling
Print version record
Subject Pathology, Molecular.
Cellular signal transduction.
Proteins.
JAK-STAT pathway.
Pathology, Molecular
Signal Transduction
protein.
Cellular signal transduction
JAK-STAT pathway
Pathology, Molecular
Proteins
Form Electronic book
Author Bell, Richard H., Jr
Staff, Northwestern University
ISBN 9781498713764
1498713769