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Title Acute myelogenous leukemia : genetics, biology and therapy / Lalitha Nagarajan, editor
Published New York : Springer, ©2010


Description 1 online resource (ix, 280 pages) : illustrations
Series CTAR ; v. 145
C.T.A.R. ; v. 145
Cancer treatment and research ; v. 145.
Contents Leukemia stem cell / Zeev Estrov.-- Epigenetic mechanisms in AML -- a target for therapy / Yasuhir Oki, Jean-Pierre J. Issa.-- Chromosomal translocations in AML: detection and prognostic significance / Nallasivam Palanisamy.-- Chromosomal deletions in AML / Lilitha Nagarajan.-- Genes predicitive of outcome and novel molecular classification schemes in adult acute myeloid leukemia / Roel G.W. Verhaak, Peter J.M. Valk.-- Receptor tyrosine kinase alterations in AML -- biology and therapy / Derek L. Stirewalt, Soheil Meshinchi.-- Lineage-specific transcription factor aberrations in AML / Beatrice U. Mueller, Thomas Pabst.-- Proleukemic RUNX1 and CBFB mutations in the pathogenesis of acute leukemia / Michael E. Engel, Scott W. Hiebert.-- Acute myeloid leukemia with mutated nucleophosmin (NPM1): molecular, pathological, and clinical features / Brunangelo Falini.-- MicroRNAs: new players in AML pathogenesis / Milena S. Nicoloso, Bharti Jasra, George A. Calin.-- Murine models of human acute myeloid leukemia / Julie M. Fortier, Timothy A. Graubert.-- Apoptosis in leukemias: regulation and therapeutic targeting / Ismael Samudio, Marina Konopleva, Bing Carter, Michael Andreeff.-- Acute promyelocytic leukemia: a pradigm for differentiation therapy / David Grimwade, Anita R. Mistry, Ellen Solomon, Fabien Guidez.-- Immunotherapy AML / Gheath Alatrash, Jeffrey J. Molldrem.-- Therapy of acute myelogenous leukemia in adults / Gautam Borthakur, Elihu E. Estey
Summary Acute myelogenous leukemia (AML), is the most common form of leukemia in adults. AML is a deadly form of malignancy, the prognosis for which has not improved in the last two decades. More importantly, it is a malignancy that is seen in older adults, therefore the number of cases is likely to rise as the population ages. Over the past 15 years, genetic mechanisms underlying AML have begun to unfold. Additional research in this area has helped identify key components and characteristics. Consequently, targeted therapy of AML is receiving much attention. It is the hope of researchers that as with chronic myelogenous leukemia (CML), and the drug, Gleevec, a targeted therapy for AML will be discovered. "The effective treatment of acute myelogenous leukemia remains a great challenge. This text reviews our understanding of the molecular and biologic basis of the disease. Leading investigators address advances in prognostication and therapeutic strategies that have significant promise."Steven T. Rosen, M.D. Series Editor
Bibliography Includes bibliographical references and index
Notes English
Print version record
Subject Acute myeloid leukemia.
Leukemia, Myeloid, Acute -- genetics
Leukemia, Myeloid, Acute -- therapy
Leukemia, Myeloid, Acute
MEDICAL -- Oncology.
HEALTH & FITNESS -- Diseases -- Cancer.
Leukemia, Myeloid, Acute.
Acute myeloid leukemia.
Acute myeloid leukemia
Form Electronic book
Author Nagarajan, Lalitha
ISBN 9780387692593