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Title The chemokine system in experimental and clinical hematology / Øystein Bruserud, editor
Published Berlin : Springer Verlag, ©2010


Description 1 online resource (xi, 206) : illustrations (some color)
Series Current topics in microbiology and immunology, 0070-217X ; 341
Current topics in microbiology and immunology ; 341. 0070-217X
Contents Part I. Introduction.-- Chemokine system in experimental and clinical hematology / Oystein Bruserud, Astrid Olsnes Kittang.-- Part II. Experimental hematology.-- Chemokine decoy receptors: strucuture-function and biological properties / Raffaella Bonecchi, Benedetta Savino, Elena M. Borroni, Alberto Mantovani, Massimo Locati.-- Role of chemokines in the biology of natural killer cells / Azzram A. Maghazachi.-- Chemokines in angiogenesis / Anna Dimbert.-- Part III. Immunobiology of allogeneic stem cell transplantation.-- Genetic polymorphisms in the cytokine and chemokine systems: their possible importance in allogeneic stem cell transplantation / Jeurgen Loeffler, Michael Ok, Oliver C. Morton, Markus Mezger, Hermann Einsele.-- Chemokine system: a possible therapeutic target in acute graft versus host disease / Nicolai A. Kittan, Gerhard C. Hildebrandt.-- Homing in on acute graft vs. host disease: tissue-specific T regulatory and Th17 cells / Brian G. Engelhardt, James E. Crowe Jr.-- Part IV: Clinical hematology.-- Chemokine network in acute myelogenous leukemia: molecular mechanisms involved in leukemogenesis and therapeutic implications / Astrid Olsnes Kittang, Kimberley Hatfield, Kristoffer Sand, Hakon Reikvam, Oystein Bruserud.-- CXCR4 in clinical hematology / Gary Calandra, Gary Bridger, Simon Fricker.-- Immunobiology of herparin-induced thrombocytopenia / Per Morten Sandset
Summary The aim of the issue is to describe and explain the importance of the chemokine system in hematology. The chemokine system is probably important for many aspects of normal as well as malignant hematopoiesis. A major focus is the development and treatment of hematologic malignancies, including the immunobiology of stem cell transplantation. The present reviews illustrate that chemokines can be involved in leukemogenesis. The chemokine system is also important both for the crosstalk between malignant cells and their neighbouring nonmalignant stromal cells (including endothelial cells) as well as
Bibliography Includes bibliographical references and index
Subject Chemokines.
Hematology, Experimental.
Blood -- Diseases.
Stem cells -- Transplantation.
Chemokines -- therapeutic use
Chemotaxis, Leukocyte -- physiology
Graft vs Host Disease -- physiopathology
Leukemia, Myeloid, Acute -- physiopathology
Receptors, Chemokine -- therapeutic use
Stem Cell Transplantation
Hematologic Diseases
MEDICAL -- Immunology.
Stem cells -- Transplantation
Blood -- Diseases
Hematology, Experimental
Genre/Form Aufsatzsammlung.
Form Electronic book
Author Bruserud, Øystein.
ISBN 9783642126390