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Title Chronic lymphocytic leukemia : methods and protocols / edited by Sami N. Malek
Published New York : Humana Press : Springer, [2018]
©2019

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Description 1 online resource (xii, 373 pages) : illustrations (some color)
Series Methods in molecular biology, 1940-6029 ; 1881
Methods in molecular biology (Clifton, N.J.) ; v. 1881. 1064-3745
Contents Ex-vivo signal transduction studies in chronic lymphocytic leukemia / Karly-Rai Rogers-Broadway, Laura I. Karydis, Rachel C. Dobson, and Andrew J. Steele -- Ex vivo pharmacological profiling in chronic lymphocytic leukemia cells / Burcu Aslan, Mary L. Ayres, and Varsha Gandhi -- Culture and harvest of CpG-stimulated peripheral blood or bone marrow in chronic lymphocytic leukemia / Cecelia R. Miller and Nyla A. Heerema -- Analysis of common abnormalities seen in chronic lymphocytic leukemia using fluorescence in situ hybridization / Reid G. Meyer and Daniel L. Van Dyke -- Immunoglobulin gene analysis in chronic lymphocytic leukemia / Andreas Agathangelidis, Richard Rosenquist, Frederic Davi, Paolo Ghia, Chrysoula Belessi, Anastasia Hadzidimitriou, and Kostas Stamatopoulos -- Detection and functional analysis of TP53 mutations in CLL / Sarka Pavlova, Jana Smardova, Nikola Tom, and Martin Trbusek -- Development and use of scalable systems for studying aberrant splicing in SF3B1-mutant CLL / Tushar Murthy, Kiran V. Paul, Alexander C. Minella, and Manoj M. Pillai -- Methods for investigating VLA-4 (CD49d/CD29) expression and activation in chronic lymphocytic leukemia and its clinical applications / Antonella Zucchetto, Erika Tissino, Alexander Chigaev, Tanja Nicole Hartmann, and Valter Gattei -- In vitro assay to study CLL and monocyte interactions / Maria Teresa Sabrina Bertilaccio, Ronghua Zhang, Priyanka Banerjee, and Varsha Gandhi -- Extracellular flux assays to determine oxidative phosphorylation and glycolysis in chronic lymphocytic leukemia cells / Hima V. Vangapandu and Varsha Gandhi -- Measurement of leukemic B-cell growth kinetics in patients with chronic lymphocytic leukemia / Andrea N. Mazzarello, Mark Fitch, Marc K. Hellerstein, and Nicholas Chiorazzi -- Assays on DNA damage and repair in CLL / Tzung-Huei Lai and Deepa Sampath -- Method for generating a patient-derived xenograft model of CLL / Shih-Shih Chen -- Immunological methods to study monoclonal antibody activity in chronic lymphocytic leukaemia / M.J. Carter, L.N. Dahal, K.L.S. Cleary, M.J.E. Marshall, R.R. French, S.A. Beers, and M.S. Cragg -- CRISPR/Cas9-based gene dropout screens / Kai Wu and Sami N. Malek -- Gene disruption using CRISPR-Cas9 technology / Nan Hu and Sami N. Malek -- Minimal residual disease quantification in chronic lymphocytic leukemia : clinical significance and flow cytometric methods / Sebastian Bottcher -- Rare variant quantitation using droplet digital PCR / Brian Parkin -- Methods for measuring ctDNA in lymphomas / Davide Rossi, Adalgisa Condoluci, Valeria Spina, and Gianluca Gaidano -- Measurement of miRNAs in chronic lymphocytic leukemia patient samples by quantitative reverse transcription PCR / Katrien Van Roosbroeck, Recep Bayraktar, and George A. Calin -- Bioinformatics analysis of whole exome sequencing data / Peter J. Ulintz, Weisheng Wu, and Chris M. Gates -- Genome sequencing and analysis methods in chronic lymphocytic leukemia / Vıctor Quesada, Miguel Araujo-Voces, Jose G. Perez-Silva, Gloria Velasco, and Carlos L opez-Otin -- Characterization of somatically-acquired copy number alterations in chronic lymphocytic leukaemia using shallow whole genome sequencing / Helen Parker, Louise Carr, Sharma Syeda, Dean Bryant, and Jonathan C. Strefford -- High-throughput sequencing of the T-cell receptor beta chain gene repertoire in chronic lymphocytic leukemia / E. Vlachonikola, A. Vardi, K. Stamatopoulos, and A. Hadzidimitriou
Summary This book aims to provide scientists with tools and well-researched protocols to enable their research and to facilitate further progress in this common leukemia. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and cutting-edge, Chronic Lymphocytic Leukemia: Methods and Protocols aims to accelerate research on chronic lymphocytic leukemia and further improvements in patient outcomes
Bibliography Includes bibliographical references and index
Notes Online resource; title from PDF title page (SpringerLink, viewed October 22, 2018)
Subject Chronic lymphocytic leukemia -- Laboratory manuals
Chronic lymphocytic leukemia.
Leukemia, Lymphocytic, Chronic, B-Cell
Chronic lymphocytic leukemia
Genre/Form Electronic books
Laboratory manuals
Laboratory manuals.
Manuels de laboratoire.
Form Electronic book
Author Malek, Sami, editor.
ISBN 9781493988761
149398876X
9781493988754
1493988751