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Author Bhargava, Manorama, author.

Title Hematologic malignancies : case studies in cytogenetic and molecular genetics / Manorama Bhargava
Published Singapore : Springer, [2021]


Description 1 online resource (261 pages)
Contents Techniques in Cytogenetics -- Techniques in Molecular Haematology -- Part: I -- Case Studies in Myeloid Malignancies -- Acute Myeloid Leukemia -- Myelodysplastic Syndrome -- Myelodysplastic Syndromes -- Myeloproliferative Neoplasms -- Myeloproliferative Neoplasms -- Chronic Myeloid Leukemia -- Next Generation Sequencing for Diagnostics of Myeloid Malignancies for Routine Clinical Use: Pitfalls and Advantages -- Part: II -- Case Studies in Lymphoid Malignancies -- Acute Lymphoblastic Leukemia -- Chronic Lymphocytic Leukemia and Non Hodgkins Lymphoma -- Part: III -- Case Studies in Multiple Myeloma -- Multiple Myeloma
Summary This book is a compendium of case studies in hematologic malignancies such as acute leukemias, myelodysplastic and myeloproliferative neoplasms, chronic leukemias and multiple myeloma covering cytogenetics (karyotyping Fluorescence in sitn hybridization (FISH)) and molecular studies in detail. The first few chapters describe the methodology employed for karyotyping, FISH and Real Time PCR technology conducive to establishment of these labs if required. Each case study is described in detail by including the clinical history of the patient, findings of peripheral blood, bone marrow aspirate and bone biopsy morphological details. This is then followed by flowcytometric immunophenotyping, cytogenetic and molecular observations leading collectively to a final diagnosis, A discussion follows based on the relevance of this data in informing the prognosis, treatment response and survival in these patients. Additionally, this data serves as a key determinant for clinical decision making involving evidence based rational management of patients including targeted therapy. For better understanding, each case study is accompanied by black and white or colour images as appropriate. This book is a source of learning and a valuable read for clinical hematologists, hematopathologists, medical oncologists, residents, interns, DM Hematology students and DNB Hematology students as well
Bibliography Includes bibliographical references
Notes Print version record
Subject Leukemia -- Genetic aspects -- Case studies
Bone marrow -- Diseases -- Genetic aspects -- Case studies
Blood -- Diseases -- Genetic aspects -- Case studies
Leukemia -- Genetic aspects
Genre/Form Electronic books
Case studies
Case studies.
√Čtudes de cas.
Form Electronic book
ISBN 9789813347991