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Book Cover
Author International Conference on B Cell Biology (11th : 2006 : Newport Beach, Calif.)

Title Mechanisms of lymphocyte activation and immune regulation XI : B cell biology / edited by Sudhir Gupta [and others]
Published New York : Springer, 2007


Description 1 online resource (x, 196 pages) : illustrations
Series Advances in experimental medicine and biology ; v. 596
Advances in experimental medicine and biology ; v. 596.
Contents B cell development and immunoglobulin gene rearrangement. Regulation and function of the E2A proteins in B cell development / Cornelis Murre. Multiple roles for blimp-1 in B and T lymphocytes / David Savitsky [and others] Memory B cell evolution: B cell biology / Louise J. McHeyzer-Williams and Michael G. McHeyzer-Williams. BCR-linked factors in developmental fate decisions / Randall J. Brezski and John G. Monroe. Gene regulatory networks that orchestrate the development of B lymphocyte precursors / Harinder Singh, Jagan M.R. Pongubala, and Kay L. Medina. Rules for the rearrangement events at the L chain gene loci of the mouse / Fritz Melchers [and others] Regulation of AID function in vivo / Reiko Shinkura [and others] Targeting of AID to immunoglobulin genes / Ursula Storb [and others] Targeting AID to the IG genes / Ziqiang Li [and others] DNA replication to aid somatic hypermutation / Zhenming Xu [and others] -- Cell signalling recepton editing tolerance and autoimmunity. Regulation of activation induced deaminase via phosphorylation / Uttiya Basu [and others] Modulation of MHC class II signal transduction by CD19 / David M. Mills, John C. Stolpa, and John C. Cambier. Role of NF[kappa]B signaling in normal and malignant B cell development / Yoshiteru Sasaki [and others] Fc receptor-like proteins (FCRL): immunomodulators of B cell function / Götz R.A. Ehrhardt [and others] Tolerance mechanisms in the late phase of the antibody response / Christopher C. Goodnow [and others] Role of RS/[kappa]DE in B cell receptor editing / José Luis Vela and David Nemazee. The regulation of receptor editing / Mark S. Schlissel. B cell hyporesponsiveness and autoimmunity: a new paradigm / Christine Grimaldi [and others]
Summary In recent years, major developments have been made in understanding various genetic and epigenetic regulatory processes that are critical for the generation of B cell repertoires. These include the role of chromatin regulation and nuclear organization in understating the IgH gene regulation. A role and mechanism of DNA repair proteins in somatic hypermutation has been elucidated. Genetic mutation studies have been instrumental in providing insight into some of the mechanisms involved in targeting CSR to various switch DNA regions located upstream of C region genes, especially a role of AID motifs, transcription, and R-loops. Recent studies support a dominant role of receptor editing in central B cell tolerance and signaling pathways that regulate receptor editing in self-reactive and non-self-reactive immature B cells. These were some of the topics of discussion at the 11th International Conference on B cell Biology. These proceedings highlight recent developments in lymphocyte development, Ig gene rearrangements and somatic hypermutation, chromatin structure modification, B lymphocyte signaling and fate, receptor editing, and autoimmunity
Analysis immunologie
infectious diseases
biomedische wetenschappen
Medicine (General)
Geneeskunde (algemeen)
Notes "Proceedings from the 11th International Conference on B cell Biology held in Newport Beach, CA, February 3-5 2006"--Title page verso
Bibliography Includes bibliographical references and index
Notes Master and use copy. Digital master created according to Benchmark for Faithful Digital Reproductions of Monographs and Serials, Version 1. Digital Library Federation, December 2002. MiAaHDL
Print version record
digitized 2010 HathiTrust Digital Library committed to preserve pda MiAaHDL
Subject Lymphocyte transformation -- Congresses
Immune response -- Regulation -- Congresses
Lymphocyte transformation.
Natural immunity.
Immune response -- Regulation.
Lymphocyte Activation
Immunity, Innate
Lymphocytes -- physiology
MEDICAL -- Immunology.
Lymphocyte transformation.
Immune response -- Regulation.
Sciences sociales.
Sciences humaines.
Immune response -- Regulation.
Lymphocyte transformation.
Genre/Form Conference papers and proceedings.
Conference papers and proceedings.
Actes de congrès.
Form Electronic book
Author Gupta, Sudhir
ISBN 9780387465302