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Title Lymphocyte trafficking in health and disease / Raffaele Badolato, Silvano Sozzani, editors
Published Basel ; Boston : Birkhauser, 2006


Description 1 online resource (x, 247 pages) : illustrations
Series Progress in inflammation research
PIR (Series)
Contents Lymphocyte trafficking: from immunology paradigms to disease mechanisms -- Lymphocyte trafficking: from immunology paradigms to disease mechanisms -- Physiology of lymphocyte trafficking -- Biology of chemokines -- Lymphocyte-endothelial cell interaction -- Chemokine receptor expression in effector and memory T cell subsets -- Migration of dendritic cell subsets -- Migration of NK cells -- Immunopathology of lymphocyte trafficking -- Lymphocyte trafficking and chemokine receptors during pulmonary disease -- Lymphocyte migration to the brain -- Lymphocyte migration to the kidney -- Leukocyte migration to pancreatic islets: a critical step in the pathogenesis of type 1 diabetes -- Controlling leukocyte trafficking in disease -- Inherited disorders of lymphocyte trafficking -- Leukocyte adhesion deficiency -- Wiskott-Aldrich syndrome as a model of cytoskeleton defects -- From CXCR4 mutations to WHIM syndrome
Summary Since the discovery of chemokines and of chemokine receptors it has become evident that expression of chemokines at the site of inflammation may regulate the composition of cellular infiltrate, thereby directing the type of immune response. Recently, the molecular characterization of inherited disorders of immune system, (e.g., Wiskott-Aldrich syndrome, WHIM syndrome, leukocyte adhesion deficiency), which are characterized by cytoskeleton/adhesion defects or by altered response of chemokine receptors has contributed to clarifying the key players of immune response in normal physiology and in disease. This book, which deals with the description of the role of chemokines in immune response and underlines potential targets of therapeutical intervention, offers a series of contributions of the most challenging aspects of lymphocyte migration in homeostasis and in disease
Bibliography Includes bibliographical references and index
In Springer e-books
Subject Lymphocytes.
Biological transport.
Immunological deficiency syndromes.
Chemokines -- metabolism
Immunologic Deficiency Syndromes
Lymphocytes -- metabolism
Biological Transport
MEDICAL -- Immunology.
Lymphocytes -- Metabolism.
Biological transport.
Chemokines -- metabolism.
Immunologic deficiency syndromes.
Sciences de la vie.
Immunological deficiency syndromes.
Biological transport.
Form Electronic book
Author Badolato, Raffaele, 1965-
Sozzani, Silvano
ISBN 3764373083