Limit search to available items
Book Cover

Title Molecular basis for therapy of AIDS-defining cancers / Dirk P. Dittmer, Susan E. Krown, editors
Published New York : Springer, ©2010


Description 1 online resource (xiii, 256 pages) : illustrations
Contents Cover13; -- Foreword -- Contents -- Contributors -- The Epidemiology of Cancer in People with HIV -- Kaposis Sarcoma -- Kaposi's Sarcoma in the Pre-HAART Era -- Kaposi's Sarcoma in the HAART Era -- Non-Hodgkin Lymphoma -- HIV-Associated NHL Since the Introduction of HAART -- Cervical Cancer -- Anal Cancer -- Hodgkin Lymphoma -- HPV-Related Anogenital and Head and Neck Cancers -- Conjunctival Cancer -- Liver Cancer -- Lung Cancer -- Non-melanoma Skin Cancer -- Conclusion -- References -- Epidemiology and Clinical Characteristicsof Non-AIDS-Defining Malignancies -- Introduction -- Epidemiology -- Studies Comparing the Pre-HAART Era and the HAART Era -- Studies Linking Risk of Cancer to Level of Immunosuppression -- The Effect of Interrupted Antiretroviral Therapy on the Risk of Cancers -- Meta-analysis Comparing HIV-Infected Individuals to Solid Organ Transplant Recipients -- Hodgkin Disease -- Clinical Presentation of HL -- Treatment of HL -- Chemotherapy and HAART -- Anal Cancer -- Clinical Features of Anal Cancer -- Anal Cancer Treatment and Outcomes -- Screening for Anal Cancer -- Effect of HAART on Anal Dysplasia -- Lung Cancer -- The Effect of HAART on the Incidence of Lung Cancer -- Contribution of Smoking Tobacco to Risk of HIV-Related Lung Cancer -- Clinical Characteristics of HIV-Positive Patients with Lung Cancer -- Treatment and Outcomes of Lung Cancer in the HAART Era -- Conclusions -- References -- HIV-Related Cancer Management in Resource-Limited Settings: A Case Study of Malawi -- Overview of Malawi Health-Care System -- HIV in Malawi -- Cancer in Malawi -- Surveillance -- HIV-Related Malignancies in Malawi -- Prevention and Early Detection -- Treatment and Management -- Treatment -- Palliative Care -- Treatment of Common HIV-Related Malignancies in Malawi -- Strategies for Improving HIV-Related Malignancy Care -- Surveillance -- Prevention -- Treatment -- Training -- Partnerships -- Research -- Summary -- References -- Immunology of HIV-Associated Kaposi Sarcoma -- Introduction -- Immunity and Cancer -- Murine Models -- Evidence for the Role of Immunity in Cancer Surveillance in Humans -- Kaposi Sarcoma -- Impact of HIV-Related Immunodeficiency on the Development of KS -- Other Factors Affecting KS Risk -- Host Factors -- Environmental Factors -- Viral Factors -- Highly Active Antiretroviral Therapy (HAART) and Immune Reconstitution -- Quantitative and Qualitative HAART-Associated Immune Reconstitution -- HAART and KS -- HAART-Associated Anti-HHV-8 Immune Reconstitution -- HAART Effects on KS Independent of Anti-HHV-8 Immune Reconstitution -- KS Development and Persistence Despite HAART -- Immune Reconstitution Inflammatory Syndrome (IRIS) -- IRIS and Cancer -- Conclusion -- References -- Targeting Signal Transduction Pathways for the Treatment of Kaposi Sarcoma -- Introduction -- Biology of Kaposi Sarcoma -- Therapeutic Opportunities -- Summary -- References -- Role of NF-B Inhibitors in HIV-Related Malignancies -- The NF-B Pathway Is Central to Cell Survival -- NF-B in Cancer -- HIV/AIDS and Malignancies -- NF-B in AIDS-Associated Viral Oncogenesis -- Gamma Herpesviruses and NF-B -- Murine Gamma Herpesvirus 68 (MHV-68) -- Kaposis Sarc
Summary An increased risk for various cancers is a characteristic of people living with HIV infection. Although only three cancers - Kaposi's sarcoma, high-grade B-cell lymphomas, and invasive cervical cancer - are considered to be "AIDS-defining" conditions, are associated with oncogenic viruses, and occur with increased frequency as immune function declines, other cancer types also occur significantly more frequently in HIV-positive individuals than in the general population, but are not directly associated with clinical progression to AIDS. Notably these "non-AIDS-defining" cancers include virus-associated cancers such as anal cancer, hepatocellular cancer and Hodgkin's disease, as well as non-virus associated cancers such as lung cancer. Importantly, there are also large worldwide differences in the incidence and behavior of different AIDS-associated cancers. Although effective combination antiretroviral therapy (cART) may be sufficient in some cases to decrease the incidence or beneficially influence the course of some cancers, in other cases it fails to control cancers in people living with HIV/AIDS. Currently, more than a decade after the widespread introduction of cART, and after major advances in the basic understanding of cancer signaling pathways, we have a unique opportunity to revisit the pathobiology, epidemiology and treatment options for malignancies in people living with HIV/AIDS. Molecular Basis for Therapy of AIDS-Defining Cancers provides a primer on the science of cancer in the setting of HIV infection, as well as examples of novel treatment approaches for HIV-associated neoplasia
Bibliography Includes bibliographical references and index
Notes Print version record
In Springer eBooks
Subject Cancer.
AIDS (Disease) -- Complications.
Cancer -- Treatment.
HIV Infections -- complications
HIV Infections -- immunology
Lymphoma, AIDS-Related -- etiology
Lymphoma, AIDS-Related -- therapy
Sarcoma, Kaposi -- etiology
Sarcoma, Kaposi -- therapy
MEDICAL -- Infectious Diseases.
HEALTH & FITNESS -- Diseases -- Contagious.
Sciences de la vie.
AIDS (Disease) -- Complications
Cancer -- Treatment
Form Electronic book
Author Dittmer, Dirk Peter, 1966-
Krown, Susan E
LC no. 2010926491
ISBN 9781441915139