Title T-cell and NK-cell lymphomas : from biology to novel therapies / editors, Christiane Querfeld, Jasmine Zain and Steven T. Rosen

Published Cham, Switzerland : Springer, [2019]

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Description 1 online resource Series Cancer treatment and research ; volume 176 Cancer treatment and research ; v. 176 Contents Intro; Contents; About the Editors; 1 Epidemiology and Pathology of T- and NK-Cell Lymphomas; Abstract; 1.1 Introduction; 1.2 Epidemiology; 1.3 Nodal Peripheral T-Cell Lymphomas; 1.3.1 Angioimmunoblastic T-Cell Lymphoma and Other Nodal Lymphomas TFH-Cell Origin; 1.3.2 Peripheral T-Cell Lymphoma, NOS; 1.3.3 Anaplastic Large-Cell Lymphomas; 1.3.4 Intestinal T-Cell Lymphomas; 1.3.5 Enteropathy-Associated T-Cell Lymphoma (EATL); 1.3.6 Monomorphic Epitheliotropic Intestinal T-Cell Lymphoma (MEITL); 1.3.7 Intestinal T-Cell Lymphoma, NOS 1.3.8 Indolent T-Cell Lymphoproliferative Disorder of the Gastrointestinal Tract1.3.9 Hepatosplenic T-Cell Lymphoma; 1.4 Cutaneous T-Cell Lymphoproliferative Disorders; 1.4.1 Subcutaneous Panniculitis-like T-Cell Lymphoma (SPTCL); 1.4.2 Primary Cutaneous Gamma-Delta T-Cell Lymphoma (PCGD-TCL); 1.4.3 Mycosis Fungoides; 1.4.4 Sézary Syndrome; 1.5 Adult T-Cell Leukemia/Lymphoma; 1.6 Extranodal NK/T-Cell Lymphoma, Nasal Type (ENKTCL); 1.7 Conclusion; References; 2 Molecular and Genomic Landscape of Peripheral T-Cell Lymphoma; Abstract; 2.1 Introduction 2.2 T-Cell Development and Activation: An Overview2.3 TCR Rearrangement in the Diagnosis of PTCL; 2.4 Pathobiology of PTCL with Molecular Genomic Approaches; 2.5 Peripheral T-Cell Lymphoma, Not Otherwise Specified (PTCL-NOS); 2.6 Gene Expression Profiling Revealed Biological Subgroups in PTCL-NOS; 2.7 Genetic Studies Demonstrated Distinct Entities Within PTCL-NOS; 2.8 Limited MicroRNA Profiling Studies in PTCL-NOS; 2.9 Angioimmunoblastic T-Cell Lymphoma (AITL); 2.10 Anaplastic Large Cell Lymphoma (ALCL); 2.11 Adult T-Cell Leukemia/Lymphoma (ATLL); 2.12 Cutaneous T-Cell Lymphoma (CTCL) 2.13 ENK/T-Cell Lymphomas2.14 The Expanding Scope of Genomics for Therapeutic Opportunities in PTCLs; References; 3 Tumor Microenvironment in T-Cell Lymphomas; Abstract; 3.1 Introduction; 3.2 Components of the Tumor Microenvironment in T-Cell Lymphomas; 3.2.1 Tumor-Infiltrating Lymphocytes; 3.2.2 Intratumoral Macrophages; 3.3 Clinical Implications; 3.3.1 Therapeutic Targets; References; 4 Peripheral T-Cell Lymphoma, not Otherwise Specified (PTCL-NOS); Abstract; 4.1 Introduction; 4.2 Epidemiology and Risk Factors 4.3 Pathological Classification, Gene Expression Profiling, and Mutational Landscape4.4 Clinical Presentation and Staging; 4.5 Prognostic Factors and Risk Stratification; 4.6 Treatment Strategies; 4.6.1 Front Line; 4.6.2 High-Dose Chemotherapy (HDCT) and Autologous Hematopoietic Stem Cell Transplantation (ASCT); 4.7 Allogeneic Stem Cell Transplantation; 4.8 Treatment of Relapsed or Refractory Patients; 4.8.1 Therapy in Transplant Ineligible Patients; 4.8.2 Limited Stage and Role of Radiation; 4.8.3 CNS Involvement and Prophylaxis; References; 5 Angioimmunoblastic T-Cell Lymphoma; Abstract Summary In this book, a group of internationally distinguished lymphoma experts provide a comprehensive review of the most important advances in the biology, diagnosis, and therapy of T cell and NK cell malignancies. In particular, it demonstrates in detail how advances in our understanding of the tumor microenvironment and molecular biology have helped to elucidate the pathogenesis of these lymphomas, improve diagnostic and prognostic accuracy, and develop novel therapies that promise improved patient outcomes. Individual chapters are devoted to particular tumor types and subtypes, and all aspects of transplantation for patients with T cell and NK cell lymphomas are discussed. As such, the book offers a valuable resource for hematologists, oncologists, hematopathologists, and all those seeking an up-to-date overview of how new, targeted therapies are delivering better disease control and improved quality of life Bibliography Includes bibliographical references Notes Online resource; title from PDF title page (EBSCO, January 3, 2019) Subject Lymphomas. T cells. Killer cells. Lymphoma -- physiopathology Lymphoma -- therapy T-Lymphocytes -- pathology Killer Cells, Natural -- pathology Lymphoma HEALTH & FITNESS -- Diseases -- General. MEDICAL -- Clinical Medicine. MEDICAL -- Diseases. MEDICAL -- Evidence-Based Medicine. MEDICAL -- Internal Medicine. Killer cells Lymphomas T cells Form Electronic book Author Querfeld, Christiane, editor Zain, Jasmine, editor Rosen, Steven T., editor ISBN 9783319997162 3319997165

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