Title Accelerating the development of biomarkers for drug safety : workshop summary / Steve Olson, Sally Robinson and Robert Giffin, rapporteurs ; Forum on Drug Discovery, Development, and Translation, Board on Health Sciences Policy, Institute of Medicine of the National Academies

Published Washington, D.C. : National Academies Press, ©2009

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Description 1 online resource (xiv, 84 pages) : illustrations Contents Introduction -- Overview Of key issues -- Cardiac safety biomarkers -- Assessing and predicting kidney safety -- Biomarkers of acute idiosyncratic hepatocellular injury in clinical trials -- Future considerations Summary "Biomarkers can be defined as indicators of any biologic state, and they are central to the future of medicine. As the cost of developing drugs has risen in recent years, reducing the number of new drugs approved for use, biomarker development may be a way to cut costs, enhance safety, and provide a more focused and rational pathway to drug development. On October 24, 2008, the IOM's Forum on Drug Discovery, Development, and Translation held "Assessing and Accelerating Development of Biomarkers for Drug Safety," a one-day workshop, summarized in this volume, on the value of biomarkers in helping to determine drug safety during development." Bibliography Includes bibliographical references Notes English Print version record Subject Biochemical markers -- Congresses Drugs -- Safety measures -- Congresses Drugs -- Testing -- Congresses Drugs -- Side effects. Biochemical markers. Drugs -- Design. Drug-Related Side Effects and Adverse Reactions Biomarkers Drug Design Drug Discovery MEDICAL -- Laboratory Medicine. MEDICAL -- Diagnosis. MEDICAL -- Nursing -- Assessment & Diagnosis. Drugs -- Side effects Drugs -- Design Biochemical markers Drugs -- Safety measures Drugs -- Testing Genre/Form proceedings (reports) Conference papers and proceedings Conference papers and proceedings. Actes de congrès. Form Electronic book Author Olson, Steve, 1956- Robinson, Sally Giffin, Robert B Institute of Medicine (U.S.). Forum on Drug Discovery, Development, and Translation. ISBN 9780309131254 0309131251 0309131243 9780309131247 1282272659 9781282272651 9786612272653 6612272651 0309142318 9780309142311

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