Title Malaria : genetic and evolutionary aspects / [edited by] Krishna R. Dronamraju and Paolo Arese

Published New York, NY : Springer, ©2006

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Description 1 online resource (xi, 190 pages) : illustrations, maps Series Emerging infectious diseases of the 21st century Emerging infectious diseases of the 21st century. Contents J.B.S. Haldane (1892-1964) / Krishna R. Dronamraju -- Removal of early parasite forms from circulation as a mechanism of resistance against malaria in widespread red blood cell mutations / Paolo Arese [and others] -- Clinical, epidemiological, and genetic investigations on thalassemia and malaria in Italy / Stefano Canali and Gilberto Corbellini -- Resistance to antimalarial drugs : parasite and host genetic factors / Rajeev K. Mehlotra and Peter A. Zimmerman -- Evolutionary origins of human malaria parasites / Stephen M. Rich and Francisco J. Ayala -- Vector genetics in malaria control / V.P. Sharma -- The rate of mutation of human genes / J.B.S. Haldane -- Disease and evolution / J.B.S. Haldane Summary This book was originally conceived at a conference at the University of Turin in Italy. The conference was organized to examine the so-called "Malaria Hypothesis", that is to say, the higher fitness of t- lassemia heterozygotes in a malarial environment, and to pay tribute to the proponent of that hypothesis, J.B.S. Haldane. Contributors to this book examine certain genetic and evolutionary aspects of malaria which is a major killer of human populations, especially in Africa and Asia. There were attempts to discredit Haldane's contribution from two directions: (a) it has been suggested that the "Malaria Hypothesis" was known long before Haldane and that there was nothing original about his idea (Lederberg 1999), and that (b) the hypothesis of heterozygote su- riority was first suggested by the Italian biologist Giuseppe Montalenti who communicated his idea to Haldane (Allison 2004). Surely, both c- not be right. In fact, the evidence presented in this book clearly indicates that both are wrong. Haldane's malaria hypothesis has stimulated a great deal of research on the genetic, evolutionary and epidemiological aspects of malaria d- ing the last 50 years. It has opened up a whole new chapter in the study of infectious diseases. It deserves serious consideration. For helpful discussions we thank Lucio Luzzatto, Alberto Piazza, Guido Modiano and David Roberts Analysis wetenschap science Sciences (General) Empirische wetenschappen (algemeen) Bibliography Includes bibliographical references Notes Primarily English, but last chapter has summaries and discussion also in French, German and Italian Print version record In Springer e-books SUBJECT Haldane, J. B. S (John Burdon Sanderson), 1892-1964 Haldane, J. B. S., 1892-1964. cct Subject Malaria. Malaria -- Genetic aspects Malaria MEDICAL -- Infectious Diseases. HEALTH & FITNESS -- Diseases -- Contagious. Malaria -- Genetic aspects. Malaria -- genetics. Evolution, Molecular. Malaria -- prevention & control. Malaria. Sciences sociales. Sciences humaines. Malaria Malaria -- Genetic aspects Genre/Form proceedings (reports) Conference papers and proceedings Festschriften. Conference papers and proceedings. Actes de congrès. Form Electronic book Author Dronamraju, Krishna R Arese, Paolo ISBN 9780387282954 0387282955 0387282947 9780387282947 6610612250 9786610612253 1280612258 9781280612251

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