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Book Cover
E-book
Author Dvorak, Ann M.

Title Ultrastructure of mast cells and basophils / Ann M. Dvorak
Published Basel ; New York : Karger, 2005

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Description 1 online resource (xi, 351 pages) : 185 figure (4 color)
Series Chemical immunology and allergy, 1660-2242 ; v. 85
Chemical immunology and allergy ; v. 85. 1660-2242
Contents Ultrastructure analysis is necessary and sufficient for identification of basophils and mast cells -- Cyclooxygenase, a key enzyme family for production of prostaglandins, is present in human mast cell lipid bodies -- Subcellular localization of the cytokines, basic fibroblast growth factor and tumor necrosis factor-alpha in mast cells -- Immunogold ultrastructural techniques identify subcellular sites of chymase, charcot-leyden crystal protein, and histamine in basophils and mast cells -- Ultrastructural enzyme-affinity-gold and inhibitor-gold techniques identify subcellular sites of histamine and heparin in basophils and mast cells -- Piecemeal degranulation of basophils and mast cells is effected by vesicular transport of stored secretory granule contents -- Mast cell-derived mediators of enhanced microvascular permeability, vascular permeability factor/ vascular endothelial growth factor, histamine, and serotonin, cause leakage of macromolecules through a new endothelial cell permeability organelle, the vesiculo-vacuolar organelle -- Degranulation and recovery from degranulation of basophils and mast cells -- Mast cell secretory granules and lipid bodies contain the necessary machinery important for the in situ synthesis of proteins
Summary Basophils and mast cells are similar but unique secretory cells which play a central role in inflammatory and immediate allergic reactions. In this book, the author reviews the ultrastructural studies of basophils and mast cells performed since the publication of an earlier monograph in 1991. These studies include the use of ultrastructural rules that allow identification of basophils and mast cells in new circumstances. The secretory granules and lipid bodies present in these cells are established as different, important organelles. A number of standard and newly developed ultrastructural ima
Bibliography Includes bibliographical references and index
Notes Print version record
Subject Mast cells.
Basophils.
Basophils -- ultrastructure
Mast Cells -- ultrastructure
Mast Cells
Basophils
Basophils -- physiology
Mast Cells -- physiology
MEDICAL -- Immunology.
Basophils
Mast cells
Mastzelle
Ultrastruktur
Basophile Zelle
Form Electronic book
ISBN 1423713842
9781423713845
9783805578646
3805578644
9783318011753
3318011754