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Title Metastasis research protocols / edited by Susan A. Brooks and Udo Schumacher
Published Totowa, N.J. : Humana Press, 2001-

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Description 1 online resource (volumes <1>) : illustrations (some color)
Series Methods in molecular medicine ; 57
Methods in molecular medicine ; 57.
Contents v. 1. Analysis of cells and tissues
Summary Although ninety percent of fatal cancer cases involve the spread of a primary tumor, the formation of metastases is still a poorly understood, complex process and a significant problem in the treatment of cancer patients. In Metastasis Research Protocols, leading international investigators describe the key methods needed to investigate why and how metastasis occurs. Volume I of this two-volume set, Analysis of Cells and Tissues, presents a comprehensive collection of established and leading-edge techniques for analyzing the expression of key molecules and for examining their production at the genetic level. The work focuses on the analysis and mapping of molecules produced by cells and tissues, and on the molecular biology underlying their expression. The traditional methods range from the histopathological and the immunocytochemical to SDS-PAGE, Western blotting, and enzyme zymography. Newer and more specialized techniques for analyzing the genetic aspects of metastasis include in situ hybridization to localize mRNAs, FISH, CGH, methylation analysis of CpG islands, RT-PCR, and differential display. The second volume of this set, Analysis of Cell Behavior In Vitro and In Vivo, moves to the level of living cells and tissues to present methodologies applicable to examining metastatic behavior in vitro and in the whole animal. Comprehensive and authoritative, the two volumes of Metastasis Research Protocols constitute a gold-standard collection of readily reproducible methods for understanding the metastatic cascade-first at the cellular and molecular levels, then at the level of the whole organism-responsible for the spread of cancer and for developing novel strategies to combat its spread
Bibliography Includes bibliographical references and index
Notes Master and use copy. Digital master created according to Benchmark for Faithful Digital Reproductions of Monographs and Serials, Version 1. Digital Library Federation, December 2002. http://purl.oclc.org/DLF/benchrepro0212 MiAaHDL
digitized 2010 HathiTrust Digital Library committed to preserve pda MiAaHDL
Subject Metastasis -- Laboratory manuals
Cancer cells -- Laboratory manuals
Cytology -- Laboratory manuals
Metastasis.
Cytology -- Technique.
Tumor markers.
Neoplasm Metastasis
Cell Transformation, Neoplastic
Cytological Techniques
Biomarkers, Tumor
Tumor markers
Cytology -- Technique
Cancer cells
Cytology
Metastasis
Metastasering.
Wetenschappelijke technieken.
Genre/Form Laboratory manuals
Laboratory manuals.
Manuels de laboratoire.
Form Electronic book
Author Brooks, Susan A
Schumacher, Udo
LC no. 2001016931
ISBN 0896036103
9780896036109
0896036154
9780896036154
1592591361
9781592591367
159259137X
9781592591374