| Description |
1 online resource (xvi, 161 pages) : illustrations |
| Series |
Advances in experimental medicine and biology ; v. 700 |
|
Advances in experimental medicine and biology ; v. 700.
|
| Contents |
MicroRNA biogenesis and function : an overview / Rene F. Ketting -- Regulation of pri-miRNA processing through Smads / Akiko Hata and Brandi N. Davis -- Stimulation of pri-miR-18a processing by hnRNP A1 / Gracjan Michlewski, Sonia Guil, and Javier F. Cáceres -- KSRP promotes the maturation of a group of miRNA precursors / Michele Trabucchi [and others] -- Hormonal repression of miRNA biosynthesis through a nuclear steroid hormone receptor / Sally Fujiyama-Nakamura, Kaoru Yamagata, and Shigeaki Kato -- Autoregulatory mechanisms controlling the microprocessor / Robinson Triboulet and Richard I. Gregory -- Regulation of pre-miRNA processing / Nicolas J. Lehrbach and Eric A. Miska -- The effect of RNA editing and ADARs on miRNA biogenesis and function / Bret S.E. Heale, Liam P. Keegan, and Mary A. O'Connell -- MiRNAs need a trim regulation of miRNA activity by trim-NHL proteins / F. Gregory Wulczyn [and others] -- Properties of the regulatory RNA-binding protein HuR and its role in controlling miRNA repression / Nicole-Claudia Meisner and Witold Filipowicz -- Turnover of mature miRNAs and siRNAs in plants and algae / Heriberto Cerutti and Fadia Ibrahim |
| Summary |
Given this pervasiveness and importance of miRNA-mediated gene regulation, it should come as little surprise that miRNAs themselves are also highly regulated. However, the recent explosion of knowledge on this topic has been remarkable, providing a primary motivation for publication of this book. As miRNAs are transcribed by RNA polymerase II, the enzyme that also generates mRNAs, it was perhaps not unexpected that miRNA transcription would be subject to regulation, and we have willfully mitted this aspect from this monograph. However, what has been unexpected is the extent of post-transcripti |
| Analysis |
Biomedicine general |
|
Human Genetics |
|
Biomedicine |
|
rna |
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regulatie |
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regulation |
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transcriptie |
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transcription |
|
biomedische wetenschappen |
|
humane genetica |
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rna polymerase |
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Medicine (General) |
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Molecular Biology (General) |
|
Geneeskunde (algemeen) |
|
Moleculaire biologie (algemeen) |
| Bibliography |
Includes bibliographical references and index |
| Notes |
Print version record |
| In |
Springer eBooks |
| Subject |
Small interfering RNA.
|
|
Genetic regulation.
|
|
Biochemistry.
|
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MicroRNAs -- genetics
|
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Gene Expression Regulation -- genetics
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RNA, Small Interfering
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Gene Expression Regulation
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Biochemistry
|
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biochemistry.
|
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medicines (material)
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|
Genetic regulation
|
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Small interfering RNA
|
| Form |
Electronic book
|
| Author |
Grosshans, Helge
|
| LC no. |
2010038832 |
| ISBN |
9781441978233 |
|
1441978232 |
|
