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Title MiRNA regulation of the translational machinery / Robert E. Rhoads, editor
Published Berlin ; New York : Springer, ©2010

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Description 1 online resource (x, 115 pages) : illustrations (some color)
Series Progress in molecular and subcellular biology, 0079-6484 ; 50
Progress in molecular and subcellular biology ; 50
Contents 112610_Rhoads_FM_O.pdf; 0001090102.pdf; Chapter 1; 0001090103.pdf; Chapter 2; 3_O.pdf; Chapter 3; 0001090105.pdf; Chapter 4; 0001090106.pdf; Chapter 5; 0001090107.pdf; Chapter 6; 0001090108.pdf; Chapter 7; 112610_Rhoads_Index_O.pdf
Summary The silencing of gene expression by small interfering RNAs has been recognized for only a relatively short time, but this has transformed our understanding of both transcriptional and post-transcriptional gene regulatory mechanisms. Multiple pathways culminate in formation of an RNA-induced silencing complex (RISC) containing a member of the Argonaute protein family bound to a 22-nt RNA strand that interacts with a target mRNA or gene through Watson-Crick base pairing. One consequence is mRNA-specific inhibition of protein synthesis. Evidence has been presented for diverse mechanisms, but there is not universal agreement in the field of how RISCs affect the translational machinery. The chapters collected in this volume represent contribution by leaders in the search to understand how miRNAs affect translation. They include chapters representing work in plants and Caenorhabditis elegans, the biological systems that originally led to the discovery of small interfering RNAs, but also include chapters on mammalian systems, with special emphasis on regulation of a key tumor suppressor and a protein that restricts human immunodeficiency virus 1 (HIV-1)
Bibliography Includes bibliographical references and index
Subject Genetic translation -- Regulation
Non-coding RNA.
Gene silencing.
RNA interference.
MicroRNAs -- physiology
RNA Interference
RNA, Untranslated
Biomédecine.
Sciences de la vie.
RNA interference
Gene silencing
Non-coding RNA
Form Electronic book
Author Rhoads, Robert E., 1944-
ISBN 3642031021
9783642031021
364203103X
9783642031038
Other Titles MicroRNA regulation of the translational machinery