Title Aspergillus fumigatus : biology, clinical aspects, and molecular approaches to pathogenicity / volume editors, Axel A. Brakhage, Bernhard Jahn, Axel Schmidt

Published Basel ; New York : Karger, ©1999

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Description 1 online resource (xii, 221 pages) : illustrations (some color) Series Contributions to microbiology ; v. 2 Contributions to microbiology ; v. 2. Contents Preface -- Editorial Preface -- J.B. Georg W. Fresenius and the Description of the Species Aspergillus fumigatus -- The Genus Aspergillus with Special Regard to the Aspergillus fumigatus Group -- Pathogenesis and Clinical Presentation of Aspergillosis -- Epidemiology and Molecular Basis of the Involvement of Aspergillus fumigatus in Allergic Diseases -- Host Defense Mechanism in Aspergillus fumigatus Infections -- Antigen and DNA Patterns Characteristic of Aspergillus fumigatus -- Laboratory Diagnosis of Aspergillus fumigatus-Associated Diseases Therapy of Aspergillus fumigatus-Related Diseases -- Animal Models of A. fumigatus Infections -- Problems of Antifungal in vitro Testing in Aspergillus fumigatus -- Transformation Systems of Aspergillus fumigatus -- Interactions between Aspergillus fumigatus and Host Matrix Proteins -- Aspergillus fumigatus-Secreted Proteases As Antigenic Molecules and Virulence Factors -- Chitin Synthase Genes of Aspergillus Species -- Pigment Biosynthesis and Virulence -- Author Index -- Subject Index Summary Aspergillus fumigatus has become one of the most important fungal human pathogens in industrialized countries. It causes different diseases like allergic bronchopulmonary aspergillosis, aspergilloma, and invasive aspergillosis depending on the underlying disease as well as the immunological status of the host. A. fumigatus is today one of the most threatening aerial fungal pathogens because nosocomially acquired invasive aspergillosis typically occurs in the treatment setting for hematological malignancy. With the increasing number of immuno-compromised individuals such as AIDS and cancer patients or transplant recipients, systemic Aspergillus infections are often life-threatening with a very high mortality rate even after anti-mycotic therapy. This book provides a comprehensive overview of the classical and molecular techniques used in the isolation, analysis, diagnosis, and the identification of potential virulence factors of A. fumigatus. The pathogenesis and clinical presentation, the epidemiology and the therapy of A. fumigatus infections are discussed extensively. Compiling the most up-to-date information available, this volume will be a useful reference source for both clinical investigators and basic research scientists Bibliography Includes bibliographical references and indexes Notes Master and use copy. Digital master created according to Benchmark for Faithful Digital Reproductions of Monographs and Serials, Version 1. Digital Library Federation, December 2002. http://purl.oclc.org/DLF/benchrepro0212 MiAaHDL Print version record digitized 2010 HathiTrust Digital Library committed to preserve pda MiAaHDL Subject Aspergillus fumigatus. Aspergillosis. Aspergillus fumigatus -- pathogenicity Aspergillus fumigatus Aspergillosis Aspergillosis -- microbiology Aspergillosis Aspergillus fumigatus Aspergillus fumigatus -- pathogénicité. Aspergillose -- Microbiologie. Aspergillus fumigatus. Aspergillose. Form Electronic book Author Brakhage, Axel A Jahn, Bernhard Schmidt, Axel, 1962- LC no. 99024266 ISBN 9783318003208 3318003204

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