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Title Molecular allergy diagnostics : innovation for a better patient management / Jörg Kleine-Tebbe, Thilo Jakob, editors
Published Cham, Switzerland : Springer, 2017


Description 1 online resource
Contents Foreword 1; Foreword 2; Preface; Molecular Allergology: From Research Topic to Innovative Allergy Diagnosis; Acknowledgments; Contributors; Contents; Part I: Protein Families and Relationships; 1: Introduction to Molecular Allergology: Protein Families, Databases, and Potential Benefits; 1.1 The Era of Molecular Allergology; 1.2 Immediate-Type Allergens and Their Names; 1.3 Sequence and Structure: From T Cell to Antibody (B Cell) Epitopes; 1.4 Protein Families and Relatedness of Type I Allergens; 1.5 Databases for Clinical Practice and Research; 1.6 Potential Use of Single Allergens
1.6.1 Quantification of Allergens in Extracts1.6.2 Molecular Epidemiology; 1.6.3 Diagnostics with Single Allergens; 1.7 Scope and Limits of Interpretation; 1.8 Immunotherapy and Single Allergens; 1.9 Molecular Allergology Drives Innovation; Conclusions; References; 2: Bet v 1 and its Homologs: Triggers of Tree-Pollen Allergy and Birch Pollen-ƯAssociated Cross-Reactions; 2.1 Introduction; 2.2 Biological Facts and Characteristics; 2.2.1 Allergen Identification; 2.2.2 Family; 2.2.3 Bet v 1 and the Bet v 1 Superfamily; 2.2.4 Physiological Function of Bet v 1; 2.2.5 Characteristics
2.3 Importance of Bet v 1 and Related Allergens2.3.1 Sources of Bet v 1 and its Biological and Allergological Role; 2.3.2 Prevalence and Distribution of Sensitization; 2.3.3 Bet v 1: A Marker Allergen for Tree (Fagales Order) Pollen Sensitization and IgE Cross-Reactivity to Plant-Derived Foods; Bet v 1 Cross-Reactive Inhalant Allergens; Bet v 1 Cross-Reactive Food Allergens; 2.4 Diagnosis; 2.4.1 Airway Symptoms Caused by Tree Pollen Allergy; 2.4.2 Bet v 1-Associated Cross-Allergies to Plant-Derived Foods; 2.4.3 Added Benefits of Molecular Diagnostics Advantages of Bet v 1 in Molecular Diagnostics2.4.3.2 Possibilities of Diagnostics Using Bet v 1-Homologous Allergens; 2.5 Therapy and Recommendations; 2.6 Perspectives; 2.7 Conclusions for Clinical Practice; References; 3: The Concept of Pollen Panallergens: Profilins and Polcalcins; 3.1 Introduction; 3.2 Allergen Nomenclature; 3.3 Structure and Function of Profilins; 3.4 Relevance of Profilins; 3.5 Sensitization to Profilins; 3.6 Structure and Function of Polcalcins; 3.7 Relevance of Polcalcins; 3.8 Diagnosis of Relevant Multi-Sensitizations to Pollen
3.9 Component-Resolved Diagnosis of Panallergen Sensitizations3.10 Clinical Relevance of Panallergens; 3.11 Extract Selection for Allergen Immunotherapy (AIT); 3.12 Conclusions from a Clinical Perspective; References; 4: Stable Plant Food Allergens I: Lipid-Transfer Proteins; 4.1 Introduction; 4.2 Structure of Allergens; 4.3 Biological Function of Allergens; 4.4 Frequency of Sensitization and Geographic Distribution; 4.5 Clinical Relevance; 4.6 IgE Cross-Reactivity Between LTPs; 4.7 Diagnosis by Sensitization Tests with LTPs and LTP-ƯContaining Extracts
Summary This book, based on a recent German publication, offers an overview of basic data and recent developments in the groundbreaking field of molecular allergology. It comprehensively explores the origin and structure of single allergen molecules ("components") and their utility in improving the management of type I, IgE-mediated allergic reactions and disorders like allergic respiratory diseases, food allergies, and anaphylaxis. Highly specific testing, called component-resolved diagnostics, aims to identify and utilize single molecules. Over 200 single allergens from plant or animal sources have been applied to single or multiplex laboratory testing for the presence of allergen-specific IgE. This leap in assay sensitivity and specificity has led to three major advances in patient management: discrimination between primary allergic sensitization and complex cross-reactivity, recognition of IgE profiles for certain allergens and identification of patients most likely to benefit from allergen-specific immunotherapy. The book discusses in detail the benefits and limitations of this 21st century technology, and offers suggestions for the use of molecular allergology in routine clinical practice. It is a "must read" for physicians treating allergic patients as well as scientists interested in natural allergic molecules and their interactions with the human immune system
Notes Includes index
Online resource; title from PDF title page (SpringerLink, viewed May 24, 2017)
Subject Allergy -- Molecular diagnosis
Paediatric medicine.
Otorhinolaryngology (ENT)
Respiratory medicine.
General practice.
HEALTH & FITNESS -- Reference.
MEDICAL -- Alternative Medicine.
MEDICAL -- Atlases.
MEDICAL -- Essays.
MEDICAL -- Family & General Practice.
MEDICAL -- Holistic Medicine.
MEDICAL -- Osteopathy.
Respiratory organs -- Diseases
Form Electronic book
Author Kleine-Tebbe, Jörg, editor.
Jakob, Thilo, editor
ISBN 9783319424996