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Title Biomarkers in breast cancer : molecular diagnostics for predicting and monitoring therapeutic effect / edited by Giampietro Gasparini and Daniel F. Hayes
Published Totowa, N.J. : Humana Press, ©2006


Description 1 online resource (xi, 341 pages)
Series Cancer drug discovery and development
Cancer drug discovery and development.
Contents Guidelines for the design of clinical studies for the development and validation of therapeutically relevant biomarkers and biomarker-based classification systems / Richard M. Simon -- Analytical aspects of biomarker immunoassays in cancer research / C.G.J. (Fred) Sweep, Chris M.G. Thomas and Manfred Schmitt -- Tissue microarrays: state-of-the-art, pitfalls, and promises / Chungyeul Kim and Soonmyung Paik -- Gene expression profiling with DNA microarrays / Michele De Bortoli and Nicoletta Biglia -- Assays for gene amplification / Chungyeul Kim, Yongkuk Song, and Soonmyung Paik -- Cell kinetics / Maria Grazia Daidone, Rosella Silvestrini, and Dino Amadori -- Urokinase-type plasminogen activator and PAI-1 / Michael J. Duffy -- Predictive value of c-erbb-2 for endocrine therapy and chemotherapy in breast cancer / Vered Stearns -- Erb-b-2 as a therapeutic target / Robert Mass -- The epidermal growth factor receptor pathway as a selective -- Molecular-targeting treatment in human breast cancer / Fortunato Ciardiello, Teresa Troiani, and Giampaolo Tortora -- P-53 as a prognostic and predictive indicator / Daniela Kandioler and Raimund Jakesz -- Occult metastatic cells in breast cancer patients / Stephan Braun, Julia Seeber, and Christian Marth -- Circulating HER-2/neu / Allan Lipton [and others] -- Circulating vascular endothelial growth factor / Roberta Sarmiento [and others] -- Detection of early tumor dissemination in patients with breast cancer / Debra Hawes and Richard J. Cote -- New technologies/new markers/new challenges / Daniel F. Hayes and Giampietro Gasparini -- Index
Summary Expert laboratory and clinical researchers from around the world review how to design and evaluate studies of tumor markers and examine their use in breast cancer patients. The authors cover both the major advances in sophisticated molecular methods and the state-of-the-art in conventional prognostic and predictive indicators. Among the topics discussed are the relevance of rigorous study design and guidelines for the validation studies of new biomarkers, gene expression profiling by tissue microarrays, adjuvant systemic therapy, and the use of estrogen, progesterone, and epidermal growth fact
Analysis neoplasms
biomedische wetenschappen
Medicine (General)
Geneeskunde (algemeen)
Bibliography Includes bibliographical references and index
Notes Print version record
Subject Breast -- Cancer -- Molecular diagnosis
Breast -- Cancer -- Prognosis
Tumor markers.
Breast Neoplasms -- diagnosis
Molecular Diagnostic Techniques
Biomarkers, Tumor
MEDICAL -- Oncology.
HEALTH & FITNESS -- Diseases -- Cancer.
Breast -- Cancer -- Prognosis.
Tumor markers.
Breast Neoplasms -- diagnosis.
Molecular Diagnostic Techniques.
Tumor Markers, Biological.
Breast -- Cancer -- Molecular diagnosis.
Sciences de la vie.
Breast -- Cancer -- Molecular diagnosis
Breast -- Cancer -- Prognosis
Tumor markers
Form Electronic book
Author Gasparini, Giampietro
Hayes, Daniel, 1951-
ISBN 9781592599158