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Title Handbook of brain tumor chemotherapy, molecular therapeutics, and immunotherapy / edited by Herbert B. Newton, MD, FAAN
Edition Second edition
Published London ; San Diego, CA : Academic Press, an imprint of Elsevier, [2018]
Online access available from:
ScienceDirect eBooks    View Resource Record  
ScienceDirect eBooks    View Resource Record  


Description 1 online resource
Contents Front Cover; Handbook of Brain Tumor Chemotherapy, Molecular Therapeutics, and Immunotherapy; Copyright; Contents; Contributors; Section I: Pharmacological and Clinical Applications; Chapter 1: Overview of Brain Tumor Epidemiology and Histopathology; Epidemiology of Brain Tumors; Pathology of Central Nervous System Tumors-Introduction; Pathology of Tumors of Neuroepithelial Origin; Pathology of Tumors of the Meninges; Pathology of Primary CNS Lymphoma; Pathology of Intracranial Germ Cell Tumors; References; Chapter 2: Clinical Pharmacology of Brain Tumor Chemotherapy; Introduction
Blood-Brain Barrier in Rat Brain Tumor ModelsLocal Delivery in Rat Brain Tumor Models; Immunological Approaches in Rat Brain Tumor Models; Chemotherapy and Boron Neutron Capture in Rat Brain Tumor Models; Human Brain Tumor Xenograft Models; Blood-Brain Barrier in Human Brain Tumor Xenograft Models; Local Delivery in Human Brain Tumor Xenograft Models; Chemotherapy in Human Brain Tumor Xenograft Models; Angiogenesis in Brain Tumor Models; References; Chapter 5: Genomics and Proteomics in Neuro-Oncology; Introduction; RNA Expression Analysis; DNA Methylation Analysis; Disease Proteomics
Chapter 3: Antiepileptic Drugs and Chemotherapy: Potential Interactions and Impact on Treatment of Patients With CancerIntroduction; Mechanism of Interaction Between AEDs and CTAs; Phase I Interactions; Phase II Interactions; Other Potential Mechanisms of AED/CTA Interactions; The Impact of AED-CTA Interactions; EIAED Effects on Targeted Therapies; AED Selection in Cancer Patients; Expected Enzyme Induction Profile of New AEDs; Changing From One AED to Another; Conclusions; Disclosure; References; Chapter 4: Brain Tumor Models for Cancer Therapy; Rat Brain Tumor Models
Pharmacology and Drug DistributionSupportive Therapeutics; Corticosteroids; Gastric Acid Inhibitors; Anticonvulsants; Delivery of Chemotherapeutic Agents; Continuous Infusion; Intra-Arterial; Interstitial; Blood-Brain Barrier Disruption; Chemotherapeutic Agents; Alkylating Agents; Nitrogen Mustards; Nitrosoureas; Procarbazine; Platinum Compounds; Temozolomide; Natural Products; Vinca Alkaloids; Pyrimidine Analogs; Purine Analogs; Folic Acid Analogs; Topoisomerase Inhibitors; Camptothecin Derivatives; Conclusions; References
Preanalytic and Bioinformatic ConsiderationsTumor Expression Profiling: Medulloblastoma; Molecular Basis and Genomic Subclassification of Medulloblastomas; Tumor Expression Profiling: Glioma; Drug Discovery and Targeting; Summary; References; Further Reading; Chapter 6: Chemotherapy Resistance; Common Chemotherapeutic Agents in Gliomas; DNA Repair and Chemotherapy Resistance; Methylguanine Methyltransferase; Histone Modification; MicroRNAs and Long Noncoding RNAs; DNA Mismatch Repair; Nucleotide and Base Excision Repair; Detoxification and Other Mechanisms of Resistance
Summary Handbook of Brain Tumor Chemotherapy, Molecular Therapeutics, and Immunotherapy, Second Edition, provides a comprehensive overview of the molecular methodologies in the neuro-oncology field. There have been profound changes in the landscape of approaches to brain tumor therapy since the first edition--mainly in the areas of molecular biology and molecular therapeutics, as well as in the maturation of immunotherapy approaches (e.g., vaccines). This updated edition has a new, primary focus on multidisciplinary molecular methods, and is broadened to include the latest cutting-edge molecular biology, therapeutics, immunobiology and immunotherapy approaches. As the first comprehensive book to address the molecular research into these concepts, users will find it to be an invaluable resource on the topics discussed.Provides the most up-to-date information regarding conventional forms of cytotoxic chemotherapy, as well as the basic science and clinical application of molecular therapeutics for the treatment of brain tumorsBroadly appeals to anyone interested in neuro-oncology and the treatment of brain tumors Features updated chapters on molecular biology, molecular therapeutics, maturation of immunotherapy approaches, and a focus on multidisciplinary molecular methodsIncludes a new section on the basic science of immunology, as well as thorough updates on the use of vaccine technology and immunotherapy for the treatment of brain tumors
Bibliography Includes bibliographical references and index
Notes Online resource; title from PDF title page (EBSCO, viewed April 4, 2018)
Subject Brain Neoplasms -- drug therapy
Brain -- Tumors -- Chemotherapy -- Handbooks, manuals, etc
Immunotherapy -- Handbooks, manuals, etc
Molecular biology -- Handbooks, manuals, etc
Molecular genetics -- Handbooks, manuals, etc
HEALTH & FITNESS / Diseases / General.
MEDICAL / Chemotherapy.
MEDICAL / Clinical Medicine.
MEDICAL / Diseases.
MEDICAL / Evidence-Based Medicine.
MEDICAL / Internal Medicine.
MEDICAL / Oncology.
Molecular biology.
Molecular genetics.
Genre/Form Handbooks and manuals.
Form Electronic book
Author Newton, Herbert B., editor
ISBN 0128121017 (electronic bk.)
9780128121016 (electronic bk.)