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Title Molecular and cellular therapies for motor neuron diseases / edited by Nicholas Boulis, Deirdre O'Connor and Anthony Donsante
Published London : Academic Press is an imprint of Elsevier, [2017]


Description 1 online resource (xiii, 321 pages) : illustrations (chiefly color)
Series ClinicalKey
Contents Molecular and extracellular cues in motor neuron specification and differentiation / R.L. Swetenburg, S.L. Stice and L. Karumbaiah -- Natural history of amyotrophic lateral sclerosis / M.J. Magnussen and J.D. Glass -- Genetics of amyotrophic lateral sclerosis / K.P. Kenna, J.E. Landers and N. Ticozzi -- Molecular mechanisms of amytrophic lateral sclerosis / M. Collins and R. Bowser -- An introduction to natural history, genetic mapping, and clinical spectrum of spinal muscular atrophy / A. McDonough, L. Urquia and N. Boulis -- Genetics of spinal muscular atrophy / A.H.M. Burghes and V.L. McGovern -- Introduction to gene and stem-cell therapy / D.M. O'Connor -- Gene therapy for amytrophic lateral sclerosis / A. Dosante -- Stem cell therapy for amytrophic lateral sclerosis / K.S. Chen and E.L. Feldman -- Gene therapy for spinal muscular atrophy / M.R. Miller, E.Y. Osman and C.L. Lorson -- Cellular therapy for spinal muscular atrophy / I. Faravelli and S. Corti -- Clinical trials to date / B.J. Mader and N. Boulis
Summary "Molecular and Cellular Therapies for Motor Neuron Diseases discusses the basics of the diseases, also covering advances in research and clinical trials. The book provides a resource for students that will help them learn the basics in a detailed manner that is required for scientists and clinicians. Users will find a comprehensive overview of the background of Amyotrophic Lateral Sclerosis (ALS/Lou Gehrig's Disease) and Spinal Muscular Atrophy (SMA), along with the current understanding of their genetics and mechanisms. In addition, the book details gene and cell therapies that have been developed and their translation to clinical trials"--Publisher's description
Bibliography Includes bibliographical references and index
Notes Online resource; title from electronic title page (ScienceDirect, viewed March 26, 2018)
Subject Motor neurons -- Diseases -- Treatment
Neuromuscular diseases -- Treatment
Motor Neuron Disease -- therapy
Molecular Targeted Therapy -- methods
Cell- and Tissue-Based Therapy -- methods
HEALTH & FITNESS -- Diseases -- General.
MEDICAL -- Clinical Medicine.
MEDICAL -- Diseases.
MEDICAL -- Evidence-Based Medicine.
MEDICAL -- Internal Medicine.
Neuromuscular diseases -- Treatment.
Genre/Form Electronic books
Form Electronic book
Author Boulis, Nicholas, editor.
O'Connor, Deirdre (Deirdre M.), editor.
Donsante, Anthony, editor.
ISBN 9780128025246